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NLRP11 Knockout Cell Lines

Gene: NLRP11

Official Full Name: NLR family pyrin domain containing 11provided by HGNC

Gene Summary: This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34907 NLRP11 Knockout cell line (HCT 116) Human NLRP11 1:2~1:4 Negative Online Inquiry
KO34908 NLRP11 Knockout cell line (HEK293) Human NLRP11 1:3~1:6 Negative Online Inquiry

Background

NLRP11 Gene Knockout Cell Lines are specialized cell models that have been genetically engineered to lack the NLRP11 gene, a member of the NOD-like receptor (NLR) family, known for its role in regulating immune responses and inflammation. This knockout feature facilitates in-depth analysis of the gene's function and its impact on cellular mechanisms, allowing researchers to dissect pathways associated with immunity, autophagy, and inflammatory diseases.

The cell lines function by enabling the study of NLRP11's influence on the activation of caspase-1, cytokine maturation, and programmed cell death. By providing insights into these critical processes, researchers can examine how the absence of NLRP11 alters cellular behavior under normal and pathological conditions. This makes it an invaluable tool for exploring the gene's implications in autoimmune disorders, infections, and cancer research.

The scientific significance of NLRP11 Gene Knockout Cell Lines lies in their application across both basic research and potential clinical studies. They serve as a crucial platform for drug development, particularly in designing therapeutics targeting inflammatory pathways. Situating these knockout models in experimental designs can lead to a deeper understanding of disease mechanisms, thus contributing to innovative treatment strategies.

One of the standout advantages of these cell lines is their specificity; many existing alternatives do not fully capture the multifaceted roles of NLRP11 in cellular responses. Moreover, these models are rigorously characterized and validated, ensuring reliability in experimental outcomes, which is essential for reproducible research.

For researchers and clinicians aiming to unveil the complexities of immune regulation and inflammation, these NLRP11 Gene Knockout Cell Lines represent a critical resource. Their use can expedite discoveries in medical research and translational applications, aligning perfectly with the shifts towards precision medicine.

With a commitment to advancing scientific research, our company offers top-tier biological products, including the NLRP11 Gene Knockout Cell Lines, backed by extensive expertise in genetic engineering and cellular biology. We are dedicated to supporting the scientific community with high-quality tools that drive innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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