Gene: NKRF
Official Full Name: NFKB repressing factorprovided by HGNC
Gene Summary: This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02118 | NKRF Knockout cell line (HeLa) | Human | NKRF | 1:3~1:6 | Negative | Online Inquiry |
KO02119 | NKRF Knockout cell line (HCT 116) | Human | NKRF | 1:2~1:4 | Negative | Online Inquiry |
KO02120 | NKRF Knockout cell line (HEK293) | Human | NKRF | 1:3~1:6 | Negative | Online Inquiry |
KO02121 | NKRF Knockout cell line (A549) | Human | NKRF | 1:3~1:4 | Negative | Online Inquiry |
NKRF Gene Knockout Cell Lines are genetically engineered cell lines that have had the NKRF gene specifically disrupted or "knocked out" to study its function and contributions to various biological processes. The NKRF (Nuclear Factor Kappa B-Related Factor) is known to play a critical role in regulating immune responses, inflammation, and cellular signaling pathways. By utilizing these knockout cell lines, researchers can investigate the molecular interactions and pathways affected by the absence of NKRF, providing valuable insights into its biological function and implications in disease.
The key function of NKRF Gene Knockout Cell Lines lies in their ability to serve as an experimental system for dissecting the role of NKRF in various cellular contexts. The absence of this gene allows for the evaluation of downstream effects on transcriptional regulation, immune response modulation, and the signaling cascades normally influenced by NKRF activity. Scientists can employ these cell lines to elucidate the gene's impact on cellular behaviors such as proliferation, apoptosis, and differentiation, which are crucial for understanding pathologies like cancers, autoimmune disorders, and chronic inflammatory diseases.
From a scientific perspective, these cell lines are invaluable in research settings, enabling the investigation of gene function in conditions where NKRF dysregulation may be implicated. They can facilitate drug discovery efforts by identifying potential therapeutic targets, thus accelerating the development of new treatments. Clinically, NKRF knockout models can be utilized to simulate and study diseases, leading to breakthroughs in understanding mechanisms involved in human health.
Compared to alternatives, such as transient gene silencing methods or traditional siRNA approaches, NKRF Gene Knockout Cell Lines offer a more stable and reliable platform for long-term studies. The complete gene ablation provides consistent and reproducible results, facilitating more accurate data interpretation and hypothesis testing.
For researchers and clinicians focused on the nuances of gene function, these knockout cell lines represent a powerful tool in the quest to uncover the complexities of cell signaling pathways. They stand as a testament to our company’s commitment to providing cutting-edge biological tools that empower the scientific community. With a focus on quality and precision, we continue to innovate and support researchers in their endeavors to solve pressing biological questions.
Please note that all services are for research use only. Not intended for any clinical use.
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