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NKAIN1 Knockout Cell Lines

Gene: NKAIN1

Official Full Name: sodium/potassium transporting ATPase interacting 1provided by HGNC

Gene Summary: NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15726 NKAIN1 Knockout cell line (HCT 116) Human NKAIN1 1:2~1:4 Negative Online Inquiry
KO15727 NKAIN1 Knockout cell line (HEK293) Human NKAIN1 1:3~1:6 Negative Online Inquiry

Background

NKAIN1 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the NKAIN1 gene, a critical regulator of sodium ion homeostasis and cellular signaling pathways. By utilizing CRISPR-Cas9 gene-editing technology, these cell lines provide researchers with a powerful tool for studying the functional implications of NKAIN1 depletion in various physiological and pathological contexts.

The primary mechanism of action involves the targeted ablation of NKAIN1, which has been shown to affect cellular interactions with ion transporters and contribute to signal transduction pathways affecting cell proliferation, survival, and apoptosis. Without the presence of NKAIN1, researchers can observe alterations in sodium handling, changes in membrane potential, and the consequent effects on cellular behavior, making these cell lines invaluable for understanding diseases linked to ion transport dysregulation, such as cardiovascular and neurological disorders.

The scientific importance of NKAIN1 Gene Knockout Cell Lines extends across both research and clinical applications. They serve as vital models for elucidating the role of NKAIN1 in various disease states, offering insights into potential therapeutic targets and biomarkers. By providing a platform for drug screening and mechanistic studies, these cell lines facilitate the development of novel treatments that can specifically target NKAIN1-related pathways.

Compared to conventional knockout models, our NKAIN1 Gene Knockout Cell Lines present several advantages, including enhanced specificity, reproducibility, and faster generation times. This efficiency allows researchers to expedite their studies and achieve results with lower resource consumption, making our cell lines a cost-effective option for high-throughput screening assays.

The valuable insights gleaned from using NKAIN1 Gene Knockout Cell Lines empower researchers and clinicians to advance their studies in ion transport physiology and pathophysiology. By unlocking the intricate roles of NKAIN1, these models aid in the quest for innovative therapies and improving patient outcomes.

Our company prides itself on its expertise in developing state-of-the-art biological products backed by rigorous scientific validation and a commitment to supporting groundbreaking research. Whether for academic institutions or pharmaceutical companies, our NKAIN1 Gene Knockout Cell Lines exemplify our dedication to advancing science and providing essential tools for discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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