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NINJ1 Knockout Cell Lines

Gene: NINJ1

Official Full Name: ninjurin 1provided by HGNC

Gene Summary: The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00381 NINJ1 gRNA3-gRNA4 KO plasmid NINJ1 $850
GP00420 NINJ1 gRNA1-gRNA2 KO plasmid NINJ1 $850
GP00424 NINJ1 gRNA1-gRNA2 KO plasmid NINJ1 $850
KO00735 NINJ1 Knockout cell line (HeLa) Human NINJ1 1:3~1:6 Negative Online Inquiry
KO00984 NINJ1 Knockout cell line (A549) Human NINJ1 1:3~1:4 Negative Online Inquiry
KO09315 NINJ1 Knockout cell line (HCT 116) Human NINJ1 1:2~1:4 Negative Online Inquiry
KO09316 NINJ1 Knockout cell line (HEK293) Human NINJ1 1:3~1:6 Negative Online Inquiry

Background

NINJ1 Gene Knockout Cell Lines are genetically engineered cell cultures in which the NINJ1 gene has been specifically disrupted, enabling researchers to investigate its role in cellular processes and disease mechanisms. The NINJ1 gene encodes for a protein involved in cellular stress responses and membrane repair, making these knockout cell lines invaluable for studying the consequences of NINJ1 deficiency. By utilizing CRISPR-Cas9 technology or other gene-editing techniques, these cell lines provide a precise model for delineating the pathways governed by NINJ1 and facilitating the exploration of its potential involvement in pathologies such as neurodegenerative diseases or tumorigenesis.

The primary function of NINJ1 is to assist in the stabilization of cellular membranes, particularly under stress conditions. When NINJ1 is knocked out, researchers can observe distinct phenotypes, including altered cell viability, increased susceptibility to mechanical stress, and impaired inflammation responses. This elucidation of cellular mechanisms is critical in research environments focused on cell biology, pharmacology, and the development of therapeutic interventions.

From a scientific perspective, NINJ1 Gene Knockout Cell Lines present multiple applications in both basic and translational research, including drug discovery, gene function analysis, and the development of gene therapies. They serve as essential tools for validating hypotheses about NINJ1’s role in health and disease, offering insights that can translate into novel therapeutic strategies.

Compared to alternative models, such as transient knockdown strategies or using animal models, NINJ1 knockout cell lines provide robust, reproducible methodologies that allow for high-throughput screening and detailed mechanistic studies with fewer variables. Additionally, these cell lines can be engineered for specific cell types, increasing their versatility and applicability across various research fields.

For researchers and clinicians seeking to deepen their understanding of cellular behaviors and mechanisms tied to membrane dynamics and stress responses, NINJ1 Gene Knockout Cell Lines represent a critical investment. Their unique ability to facilitate precise inquiries into gene function and disease susceptibility underscores their value in the continuum of basic and applied biomedical research.

Our company specializes in producing high-quality cell lines, leveraging advanced gene-editing technologies and a commitment to rigorous scientific standards. We offer a comprehensive portfolio tailored to meet the diverse needs of researchers in the field, ensuring reliability and reproducibility in every experiment.

Please note that all services are for research use only. Not intended for any clinical use.

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