Gene: NET1
Official Full Name: neuroepithelial cell transforming 1provided by HGNC
Gene Summary: This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32031 | NET1 Knockout cell line (HeLa) | Human | NET1 | 1:3~1:6 | Negative | Online Inquiry |
KO32032 | NET1 Knockout cell line (HCT 116) | Human | NET1 | 1:2~1:4 | Negative | Online Inquiry |
KO32033 | NET1 Knockout cell line (HEK293) | Human | NET1 | 1:3~1:6 | Negative | Online Inquiry |
KO32034 | NET1 Knockout cell line (A549) | Human | NET1 | 1:3~1:4 | Negative | Online Inquiry |
NET1 Gene Knockout Cell Lines are specialized cellular models in which the NET1 gene has been precisely disrupted using advanced genome editing techniques such as CRISPR-Cas9. This innovative tool allows researchers to investigate the functional role of the NET1 gene, which encodes a protein implicated in several critical cellular processes, including the regulation of Rho GTPase signaling, cytoskeletal dynamics, and cell proliferation. By creating a knockout model, scientists can elucidate the consequences of NET1 loss on cellular behavior and understand the underlying mechanisms involved in various biological pathways.
The key mechanism of these knockout cell lines revolves around the complete cessation of NET1 protein expression, thus enabling the observation of phenotypic changes that stem from its absence. Researchers can study alterations in cell morphology, motility, and signaling pathways, which are essential for dissecting complex disease mechanisms, particularly in cancer and developmental biology.
The scientific importance of NET1 Gene Knockout Cell Lines lies in their wide-ranging applications in research and clinical settings. They serve as invaluable tools for drug discovery, functional genomics, and the development of therapeutic strategies targeting NET1-related pathways. In particular, their utilization can lead to breakthrough insights into diseases where aberrant NET1 activity is implicated, including tumor progression and metastasis.
What sets our NET1 Gene Knockout Cell Lines apart from alternatives is the precision of our gene editing approach, ensuring high specificity and efficiency in the knockout. Coupled with our rigorous quality control processes, researchers can trust the consistency and reliability of these cell lines in their experiments. Additionally, we provide comprehensive technical support and detailed characterization data, which enhances the usability and value of the product.
For researchers and clinicians, investing in NET1 Gene Knockout Cell Lines presents a significant opportunity to advance their understanding of cellular mechanisms and disease progression, ultimately leading to innovative treatments and improved patient outcomes. Our company, with its commitment to cutting-edge research and stringent quality assurance, is a leader in providing high-quality biological products that empower the scientific community to tackle pressing health challenges.
Please note that all services are for research use only. Not intended for any clinical use.
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