Gene: NCKAP1
Official Full Name: NCK associated protein 1provided by HGNC
Gene Summary: Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31522 | NCKAP1 Knockout cell line (HeLa) | Human | NCKAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO31523 | NCKAP1 Knockout cell line (HCT 116) | Human | NCKAP1 | 1:2~1:4 | Negative | Online Inquiry |
KO31524 | NCKAP1 Knockout cell line (HEK293) | Human | NCKAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO31525 | NCKAP1 Knockout cell line (A549) | Human | NCKAP1 | 1:3~1:4 | Negative | Online Inquiry |
NCKAP1 Gene Knockout Cell Lines are sophisticated biological tools specifically engineered to enable the study of the NCKAP1 gene's function through the complete deletion of its coding sequence in a cellular context. By utilizing CRISPR-Cas9 gene editing technology, these cell lines allow for precise modifications that facilitate in-depth analysis of NCKAP1’s role in various cellular processes, including cytoskeletal organization, signal transduction, and cellular motility.
The primary mechanism of action involves the introduction of targeted double-strand breaks in the NCKAP1 gene, followed by the cell's natural repair processes, which result in insertion-deletion mutations that disrupt normal gene function. This strategic knockout enables researchers to unravel the specific contributions of NCKAP1 to critical pathways associated with cell growth, differentiation, and response to stimuli, making these cell lines invaluable in exploratory and experimental research.
The scientific importance of NCKAP1 Gene Knockout Cell Lines is underscored by their application in elucidating the mechanisms underlying various diseases, particularly cancer and autoimmune disorders. By providing insights into how the absence of NCKAP1 affects cellular behavior, researchers can identify potential therapeutic targets and develop novel treatments.
Compared to traditional knockdown approaches, such as RNA interference, these knockout cell lines offer a more permanent and complete disruption of gene function, which leads to more consistent and reproducible experimental outcomes. Furthermore, they can be used in various cellular backgrounds, allowing researchers to study gene function across different tissue types.
For researchers and clinicians, the value of NCKAP1 Gene Knockout Cell Lines rests in their ability to facilitate groundbreaking discoveries in cell biology and disease pathology. By streamlining the process of gene function analysis, these cell lines are essential for advancing our understanding of gene-driven mechanisms in health and disease.
Our company specializes in the development of high-quality biological products that meet rigorous scientific standards. With our expertise in gene editing and cellular biology, we are committed to providing innovative solutions that empower researchers to enhance their investigations and translate findings into meaningful healthcare advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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