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NBN Knockout Cell Lines

Gene: NBN

Official Full Name: nibrinprovided by HGNC

Gene Summary: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03695 NBN Knockout cell line (HeLa) Human NBN 1:3~1:6 Negative Online Inquiry
KO03696 NBN Knockout cell line (HCT 116) Human NBN 1:2~1:4 Negative Online Inquiry
KO03697 NBN Knockout cell line (HEK293) Human NBN 1:3~1:6 Negative Online Inquiry
KO03698 NBN Knockout cell line (A549) Human NBN 1:3~1:4 Negative Online Inquiry

Background

NBN Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate research in the field of molecular biology and genetics. These cell lines have been genetically modified to create a knockout of the NBN gene, a critical component involved in DNA repair processes, particularly in the recognition and repair of double-strand breaks. By disabling this gene, researchers can explore the consequences of NBN deficiency, which is implicated in various diseases, including cancer and genetic disorders.

The primary mechanism of action of NBN Gene Knockout Cell Lines lies in their ability to mimic mutations found in human diseases, enabling scientists to study the pathways affected by NBN loss. This specificity allows researchers to assess the role of NBN in cellular responses to DNA damage, evaluate therapeutic resistance, and investigate potential drug targets. Their use is instrumental in elucidating the molecular mechanisms underlying genomic stability and the cellular response to genotoxic stress.

In clinical and research settings, NBN Gene Knockout Cell Lines have significant implications for developing targeted therapies and personalized medicine approaches. They serve as a powerful tool for screening potential pharmacological agents and understanding the genetic basis of disease. The unique ability of these lines to model disease-relevant mutations provides insights that can lead to breakthroughs in treatment strategies.

Compared to alternatives, such as conventional cell lines that may not accurately reflect the consequences of NBN inactivation, these knockout cell lines offer enhanced specificity and reliability. Their unparalleled ability to provide a clear understanding of the biological processes involved in NBN-related pathologies sets them apart.

For researchers and clinicians aiming to bridge the gap between basic science and clinical applications, NBN Gene Knockout Cell Lines represent an invaluable resource. They empower users to make significant advancements in their work, ultimately leading to improved therapeutic strategies and patient outcomes. Our company is committed to providing high-quality, robust biological products backed by expert knowledge and unparalleled support, ensuring that our customers achieve research excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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