Gene: N4BP2L2
Official Full Name: NEDD4 binding protein 2 like 2provided by HGNC
Gene Summary: Enables enzyme binding activity. Involved in negative regulation of hematopoietic stem cell differentiation and positive regulation of hematopoietic stem cell proliferation. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31860 | N4BP2L2 Knockout cell line (HeLa) | Human | N4BP2L2 | 1:3~1:6 | Negative | Online Inquiry |
KO31861 | N4BP2L2 Knockout cell line (HCT 116) | Human | N4BP2L2 | 1:2~1:4 | Negative | Online Inquiry |
KO31862 | N4BP2L2 Knockout cell line (HEK293) | Human | N4BP2L2 | 1:3~1:6 | Negative | Online Inquiry |
KO31863 | N4BP2L2 Knockout cell line (A549) | Human | N4BP2L2 | 1:3~1:4 | Negative | Online Inquiry |
N4BP2L2 gene knockout cell lines represent a pioneering suite of engineered cellular models specifically designed for in-depth studies of the N4BP2L2 gene's role in various biological processes. These cell lines have been meticulously crafted using CRISPR-Cas9 technology to induce precise gene knockouts, effectively ablating the function of N4BP2L2, a critical regulator involved in immune response and cellular stress signaling pathways.
The primary function of N4BP2L2 gene knockout cell lines lies in their capacity to facilitate the exploration of the gene's role in various cellular contexts. By removing N4BP2L2, researchers can investigate the resultant phenotypic changes, allowing for a clearer understanding of the gene's contribution to cellular homeostasis, apoptosis, and immune modulation. This makes them invaluable tools for elucidating disease mechanisms, particularly in cancer research and immunology, where N4BP2L2 appears to influence tumor microenvironments and immune cell responses.
The scientific importance of these knockout cell lines in both research and clinical contexts is significant. They can be employed in drug discovery efforts, enabling researchers to screen for therapeutic compounds that may restore normal function or exploit vulnerabilities arising from the loss of N4BP2L2. Furthermore, these models provide insights into potential biomarkers for disease progression and therapeutic targets, supporting precision medicine initiatives.
In terms of advantages, N4BP2L2 gene knockout cell lines offer superior specificity and reliability compared to traditional knockout methods, allowing for the generation of a homogeneous population of cells with consistent genetic alterations. This reduces experimental variability and enhances reproducibility in results. Additionally, the use of CRISPR-Cas9 technology ensures that off-target effects are minimized, further increasing the validity of the experimental outcomes.
For researchers and clinicians aiming to advance their understanding of immune mechanisms or cancer biology, these cell lines serve as crucial experimental tools that can drive new discoveries. They not only empower scientists to perform sophisticated genetic studies but also position them to make contributions that could lead to impactful advancements in therapeutic approaches.
With our extensive expertise in genetic engineering and cell biology, we are committed to providing high-quality biological products, such as N4BP2L2 gene knockout cell lines, that empower researchers to push the boundaries of scientific exploration and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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