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Mif Knockout Cell Lines

Gene: Mif

Official Full Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor)provided by MGI

Gene Summary: Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of icosanoid secretion; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cellular senescence; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00192 Mif gRNA3-gRNA4 KO plasmid Mif $850
GP00209 Mif gRNA1-gRNA2 KO plasmid Mif $850
KO01148 Mif knockout cell line (MC38) Mouse Mif 1:2-1:4 Negative Online Inquiry

Background

Mif Gene Knockout Cell Lines are genetically modified cell lines in which the macrophage migration inhibitory factor (MIF) gene has been disrupted or "knocked out." This innovative tool enables researchers to investigate the specific roles of MIF in various physiological and pathological processes. MIF is a critical regulator of immune responses and has been implicated in a range of diseases, including cancer, autoimmune disorders, and cardiovascular diseases, making these knockout lines particularly valuable for elucidating disease mechanisms and therapeutic targets.

The primary function of Mif Gene Knockout Cell Lines lies in their ability to provide a controlled environment to study the absence of MIF signaling. By comparing these knockout cells to their wild-type counterparts, researchers can investigate the downstream effects of MIF's role in cellular processes, such as inflammation, cell proliferation, and apoptosis. These cell lines can also be utilized in drug screening assays, enabling the identification of compounds that can modulate MIF-related pathways.

The scientific importance of Mif Gene Knockout Cell Lines is evident in their broad range of applications in both research and clinical settings. They facilitate a deeper understanding of immune responses, allowing scientists to develop targeted therapies that can interfere with MIF's pathway, thereby offering new treatment avenues for patients suffering from MIF-related conditions.

Compared to traditional methods of gene knockdown, such as siRNA, the knockout approach provides a more permanent and elucidative investigation of gene function, ensuring that findings are reproducible and reliable. This specificity is a unique selling point, as it allows for a more detailed exploration of MIF's multifaceted roles in health and disease.

For researchers, clinicians, and pharmaceutical developers, Mif Gene Knockout Cell Lines represent an invaluable resource for advancing biological understanding and developing novel therapeutic interventions. By leveraging our cutting-edge genetic engineering capabilities, we are committed to providing high-quality biological products that empower the scientific community. Our expertise ensures that you receive trusted, well-characterized cell lines that can drive your research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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