Gene: Mettl4
Official Full Name: methyltransferase 4, N6-adenosineprovided by MGI
Gene Summary: Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in negative regulation of gene expression, epigenetic. Predicted to be located in mitochondrial matrix and nucleus. Predicted to be active in cytosol. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01179 | Mettl4 Knockout cell line(Hepa 1-6) | Mouse | Mettl4 | 1:2~1:4 | Negative | Online Inquiry |
Mettl4 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the biological roles of the Mettl4 gene, which encodes for a methyltransferase involved in RNA methylation processes. These cell lines are created using CRISPR-Cas9 technology to create precise genetic modifications, enabling researchers to study the function of Mettl4 in cellular pathways, gene expression regulation, and its potential implications in various diseases.
The key function of Mettl4 in cellular function stems from its role in RNA modification; it catalyzes the methylation of specific adenosine residues in mRNA, which affects RNA stability, splicing, and translation efficiency. The Mettl4 Gene Knockout Cell Lines allow for high-resolution assessment of these mechanisms by providing a controlled environment where the gene’s influence can be directly observed. This can lead to breakthroughs in understanding how dysregulation of RNA methylation contributes to diseases, including cancer and neurological disorders.
The scientific importance of these cell lines cannot be overstated, as they serve as powerful tools in both fundamental research and clinical settings, particularly in drug discovery and development. They enable researchers to dissect the underlying mechanisms of disease, test therapeutic interventions, and validate potential drug targets effectively.
Mettl4 Gene Knockout Cell Lines are advantageous due to their specificity, reproducibility, and proficiency in mimicking the native biological conditions without the noise often associated with other models. Unlike traditional knockdown approaches, which can lead to off-target effects, our knockout line provides a definitive assessment of gene function, ensuring high data integrity.
For researchers and clinicians keen on exploring therapeutic avenues or conducting basic research, these cell lines present a valuable resource that fosters innovation and discovery. Our commitment at [Your Company Name] to quality and precision in developing biological tools has led us to create these advanced cell lines, ensuring that you have the best resources at your disposal for groundbreaking research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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