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MYO5A Knockout Cell Lines

Gene: MYO5A

Official Full Name: myosin VAprovided by HGNC

Gene Summary: This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1) and neuroectodermal melanolysosomal disease, or Elejalde disease. [provided by RefSeq, Sep 2023]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36500 MYO5A Knockout cell line (HeLa) Human MYO5A 1:3~1:6 Negative Online Inquiry
KO36501 MYO5A Knockout cell line (HCT 116) Human MYO5A 1:2~1:4 Negative Online Inquiry
KO36502 MYO5A Knockout cell line (HEK293) Human MYO5A 1:3~1:6 Negative Online Inquiry
KO36503 MYO5A Knockout cell line (A549) Human MYO5A 1:3~1:4 Negative Online Inquiry

Background

MYO5A Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate the study of myosin V-A (MYO5A), a critical motor protein involved in intracellular transport processes. These cell lines are created using CRISPR-Cas9 gene editing technology to selectively disrupt the MYO5A gene, enabling researchers to examine the functional consequences of MYO5A deficiency in cellular systems.

The primary function of MYO5A revolves around its role in the transport of organelles and vesicles within cells, impacting processes such as endocytosis, exocytosis, and the movement of actin filaments. By utilizing these knockout cell lines, scientists can dissect the molecular pathways that MYO5A influences, providing insights into various cellular behaviors and potential aberrations associated with diseases, including neurodegenerative conditions and cancer.

In a research or clinical context, MYO5A Gene Knockout Cell Lines are invaluable for elucidating the roles of myosin VIIs in disease mechanisms such as synaptic dysfunction or defective intracellular trafficking. The ability to simulate loss-of-function conditions allows for a more profound understanding of MYO5A’s biological importance, paving the way for the development of therapeutic interventions targeting these pathways.

When comparing these knockout cell lines to alternative models, MYO5A Gene Knockout Cell Lines stand out due to their precise genetic modification, minimal off-target effects, and versatility for various experimental applications. Researchers benefit from the reproducibility and reliability of results obtained from these focused models, making them indispensable for high-quality scientific investigations.

The value of MYO5A Gene Knockout Cell Lines is accentuated by our strong commitment to delivering advanced biological products that support cutting-edge research. Our team comprises experts in genetic engineering and cell biology, ensuring that our products meet the highest standards of quality and performance, ultimately empowering researchers and clinicians at the forefront of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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