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MYL12A Knockout Cell Lines

Gene: Myl12a

Official Full Name: myosin, light chain 12A, regulatory, non-sarcomericprovided by MGI

Gene Summary: Enables glutamate receptor binding activity. Acts upstream of or within protein localization to plasma membrane and regulation of cell shape. Located in Z disc and stress fiber. Part of myosin II complex. Orthologous to human MYL12A (myosin light chain 12A) and MYL12B (myosin light chain 12B). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31653 MYL12A Knockout cell line (HeLa) Human MYL12A 1:3~1:6 Negative Online Inquiry
KO31654 MYL12A Knockout cell line (HCT 116) Human MYL12A 1:2~1:4 Negative Online Inquiry
KO31655 MYL12A Knockout cell line (HEK293) Human MYL12A 1:3~1:6 Negative Online Inquiry
KO31656 MYL12A Knockout cell line (A549) Human MYL12A 1:3~1:4 Negative Online Inquiry

Background

Myl12a Gene Knockout Cell Lines are specialized cellular models in which the Myl12a gene, critical for certain muscle regulation processes, has been disrupted through targeted gene editing techniques. This innovative cell line allows for the precise investigation of the gene's functional role in myocyte differentiation and muscle contractility. By employing CRISPR/Cas9 technology, the Myl12a knockout offers a robust platform for elucidating gene function and signaling pathways associated with cardiac and skeletal muscle physiology.

The key mechanism behind the Myl12a Gene Knockout Cell Lines involves the intentional inactivation of the Myl12a gene, which encodes for myosin regulatory light chain protein, thereby allowing researchers to explore the consequences of this gene's absence on cellular behavior, such as proliferation, apoptosis, and metabolic function. This level of inquiry has significant implications for understanding muscle-related disorders and developing targeted therapeutic interventions.

Scientifically, these cell lines are invaluable tools for both in vitro and in vivo applications. Researchers can utilize Myl12a knockout lines to investigate the cellular and molecular mechanisms underpinning muscle development, pathophysiology in diseases like cardiomyopathy, and responses to pharmacological agents. Moreover, they provide a controlled environment for the assessment of gene regulatory networks, making them critical assets for translational research efforts.

Compared to conventional cell lines or less specific knockout models, Myl12a Gene Knockout Cell Lines standout due to their targeted approach, which enhances the reliability and relevance of experimental outcomes. They are tailored to support advanced research in muscle biology, offering researchers the ability to draw precise conclusions that could be pivotal in the realm of drug discovery and the development of regenerative medicine protocols.

Investing in Myl12a Gene Knockout Cell Lines equips scientists and clinicians with a powerful resource to accelerate their research endeavors. With our commitment to quality and innovation, our company leverages extensive experience in the production of genetically modified cell lines, ensuring reliable and reproducible models that meet the highest standards in scientific investigation.

Please note that all services are for research use only. Not intended for any clinical use.

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