Gene: MYH3
Official Full Name: myosin heavy chain 3provided by HGNC
Gene Summary: Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02686 | MYH3 Knockout cell line (HCT 116) | Human | MYH3 | 1:2~1:4 | Negative | Online Inquiry |
KO02687 | MYH3 Knockout cell line (HEK293) | Human | MYH3 | 1:3~1:6 | Negative | Online Inquiry |
KO02688 | MYH3 Knockout cell line (A549) | Human | MYH3 | 1:3~1:4 | Negative | Online Inquiry |
MYH3 Gene Knockout Cell Lines are genetically engineered cell lines that specifically lack the MYH3 gene, which encodes the myosin heavy chain 3 protein, a key component of skeletal muscle fibers. These cell lines serve as a powerful tool for researchers studying a variety of biological processes, particularly those related to muscle development, function, and pathophysiology. The knockout of the MYH3 gene enables scientists to investigate the role of this protein in muscle diseases, cellular signaling pathways, and regenerative processes.
The primary mechanism of action for MYH3 Gene Knockout Cell Lines involves the selective deletion of the MYH3 gene, which disrupts the production of the myosin heavy chain 3 protein. This results in altered contractility and functionality of muscle cells, providing researchers with insights into the molecular mechanics underlying muscle contraction and associated disorders. The knockouts are instrumental for elucidating the functions of myosin within the complex network of muscle biology, specifically in the context of developmental myopathies.
The scientific importance of MYH3 Gene Knockout Cell Lines extends beyond basic research; they have significant implications in translational medicine, particularly in the development of gene therapies and regenerative treatments for muscle-related conditions. In clinical settings, understanding the role of MYH3 could lead to breakthroughs in therapeutic strategies for myopathies such as congenital myopathy and muscular dystrophies.
Compared to traditional wild-type cell lines, MYH3 Gene Knockout Cell Lines offer an unparalleled advantage by providing a controlled environment to dissect the consequences of MYH3 gene absence on cell behavior and physiology without confounding variables. The specificity of these knockout lines enhances the clarity of experimental data, facilitating more robust conclusions in research studies.
Researchers, clinicians, and biotechnological companies can greatly benefit from using MYH3 Gene Knockout Cell Lines as they offer a unique platform for validating hypotheses and investigating novel therapeutic approaches. They are designed to accelerate the discovery phase in muscle biology, making them essential for those focused on advancing scientific understanding and clinical applications.
Our company specializes in providing high-quality genetic engineering solutions tailored to meet the needs of researchers and healthcare professionals. With a commitment to innovation and excellence, we ensure that our MYH3 Gene Knockout Cell Lines are developed with precision to support your cutting-edge research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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