Gene: MVB12B
Official Full Name: multivesicular body subunit 12Bprovided by HGNC
Gene Summary: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23919 | MVB12B Knockout cell line (HeLa) | Human | MVB12B | 1:3~1:6 | Negative | Online Inquiry |
KO23920 | MVB12B Knockout cell line (HCT 116) | Human | MVB12B | 1:2~1:4 | Negative | Online Inquiry |
KO23921 | MVB12B Knockout cell line (HEK293) | Human | MVB12B | 1:3~1:6 | Negative | Online Inquiry |
KO23922 | MVB12B Knockout cell line (A549) | Human | MVB12B | 1:3~1:4 | Negative | Online Inquiry |
MVB12B Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed for the precise study of gene function and the development of targeted therapies. These cell lines are engineered to have specific genes disrupted, enabling researchers to investigate the consequences of gene loss on cellular processes, signaling pathways, and phenotypic outcomes. The knockout approach utilized in creating MVB12B lines employs advanced CRISPR-Cas9 technology, ensuring high specificity and efficiency in gene editing.
The key function of MVB12B Gene Knockout Cell Lines lies in their ability to serve as a platform for functional genomics. By observing the cellular behavior and physiological responses in these knockout contexts, researchers can unravel the intricate roles of particular genes, contributing to a greater understanding of disease mechanisms and potential therapeutic targets. Moreover, these cell lines facilitate drug screening and biomarker identification, making them invaluable in both academic research and clinical applications.
In comparison to traditional knockout models, such as whole organism knockouts or RNA interference systems, MVB12B offers several significant advantages. They provide a more controlled environment, reduce variability seen in animal models, and allow for rapid and reproducible results. These factors enable researchers to streamline their experiments, yielding results that are both high-quality and conducive to further innovation.
For researchers and clinicians focused on gene function, disease modeling, or therapeutic development, MVB12B Gene Knockout Cell Lines offer a vital resource. Their precision and reliability can significantly advance experimental processes, fostering new breakthroughs in genetic research.
Our company, with its extensive experience in biotechnologies and commitment to innovation, ensures that MVB12B Gene Knockout Cell Lines are produced under stringent quality control measures, providing our customers with high-quality biological products that meet the demands of modern research.
Please note that all services are for research use only. Not intended for any clinical use.
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