Gene: MUL1
Official Full Name: mitochondrial E3 ubiquitin protein ligase 1provided by HGNC
Gene Summary: Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including negative regulation of defense response; positive regulation of protein metabolic process; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and peroxisome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15961 | MUL1 Knockout cell line (HeLa) | Human | MUL1 | 1:3~1:6 | Negative | Online Inquiry |
KO15962 | MUL1 Knockout cell line (HCT 116) | Human | MUL1 | 1:2~1:4 | Negative | Online Inquiry |
KO15963 | MUL1 Knockout cell line (HEK293) | Human | MUL1 | 1:3~1:6 | Negative | Online Inquiry |
KO15964 | MUL1 Knockout cell line (A549) | Human | MUL1 | 1:3~1:4 | Negative | Online Inquiry |
MUL1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to disrupt the expression of the MUL1 gene, which plays a crucial role in mitochondrial dynamics and cellular stress responses. By employing CRISPR/Cas9 technology, these knockout lines provide a reliable model to investigate the physiological and pathological roles of MUL1 in various biological processes, including apoptosis, inflammation, and neurodegenerative diseases.
The primary function of MUL1 gene knockout is to facilitate the study of mitochondrial biogenesis and degradation, as MUL1 is known to be involved in the regulation of mitophagy—the process by which damaged mitochondria are selectively degraded. The absence of MUL1 in these cell lines allows researchers to examine changes in mitochondrial function, dynamics, and cellular metabolism, thereby providing insights into the pathophysiology of diseases characterized by mitochondrial dysfunction.
In research and clinical settings, MUL1 Gene Knockout Cell Lines are invaluable tools for exploring potential therapeutic targets for conditions such as Parkinson's disease, cancer, and metabolic syndromes. They allow for the detailed dissection of molecular pathways affected by the loss of MUL1, enabling scientists to identify new avenues for drug development and innovative treatments.
Compared to other gene knockout models, our MUL1 Gene Knockout Cell Lines stand out due to their high efficiency in disruption and the extensive characterization supporting their use across a variety of cell types. Each line is thoroughly validated for Gene editing efficiency, off-target effects, and functional assays, ensuring that researchers have access to reliable and reproducible data.
For researchers and clinicians, the value of using these cell lines cannot be overstated; they enable a deeper understanding of complex biological processes and the development of novel interventions that target mitochondrial dysfunction. Our company prides itself on its commitment to providing high-quality biological products backed by cutting-edge technology and scientific expertise. By choosing our MUL1 Gene Knockout Cell Lines, you gain access to a powerful research tool that can significantly enhance your laboratory's capabilities.
Please note that all services are for research use only. Not intended for any clinical use.
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