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MTRR Knockout Cell Lines

Gene: MTRR

Official Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by HGNC

Gene Summary: This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00093 MTRR Knockout cell line (HepG2) Human MTRR 1:2~1:4 Negative Online Inquiry
KO36529 MTRR Knockout cell line (HeLa) Human MTRR 1:3~1:6 Negative Online Inquiry
KO36530 MTRR Knockout cell line (HCT 116) Human MTRR 1:2~1:4 Negative Online Inquiry
KO36531 MTRR Knockout cell line (HEK293) Human MTRR 1:3~1:6 Negative Online Inquiry
KO36532 MTRR Knockout cell line (A549) Human MTRR 1:3~1:4 Negative Online Inquiry

Background

MTRR Gene Knockout Cell Lines are genetically engineered cell models specifically designed to elucidate the functions of the methionine synthase reductase (MTRR) gene. This product allows for precise studies involving gene expression, metabolic pathways, and cellular responses linked to the regulation of homocysteine and methionine metabolism. By creating a knockout model, researchers can observe phenotypic changes and alterations in cellular function when the MTRR gene is absent, thereby providing insights into its role within various biochemical processes.

The primary function of these cell lines is to facilitate investigations into the molecular mechanisms mediated by MTRR. This encompasses examining changes in cell proliferation, differentiation, and apoptosis, particularly in the context of diseases linked to disrupted methylation cycles, such as cardiovascular diseases, neurological disorders, and certain cancers. The knockout of MTRR enhances the understanding of the relationship between genetic variation and metabolic disorders, making these cell lines invaluable tools in leading-edge biomedical research.

The scientific importance of MTRR Gene Knockout Cell Lines extends into both research and clinical applications. They are particularly useful for validating therapeutic targets and exploring drug responses in systems that mimic the pathogenic state of human cells. The capacity to dissect the role of MTRR in cell metabolism places these knockout lines at the forefront of biological inquiry.

Compared to alternative biological tools, MTRR Gene Knockout Cell Lines offer unique advantages, including high specificity for the MTRR gene, reproducibility of results, and straightforward handling in various experimental setups. This streamlined approach reduces the complexity commonly associated with traditional gene editing methods, allowing researchers to dedicate more time to analysis and interpretation.

For researchers and clinicians seeking to unravel the genetic and metabolic underpinnings of various diseases, these cell lines provide an efficient and reliable means of conducting experiments. Their availability streamlines experimental workflows and drives forward scientific discoveries in the realm of genetic and metabolic research.

At [Your Company Name], we pride ourselves on delivering high-quality biological products that enable impactful scientific discoveries. Our expertise in genetic engineering and commitment to supporting the research community ensure that MTRR Gene Knockout Cell Lines are developed with precision and rigor, making them an essential addition to any laboratory focused on advanced biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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