Gene: MTRF1L
Official Full Name: mitochondrial translation release factor 1 likeprovided by HGNC
Gene Summary: The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21664 | MTRF1L Knockout cell line (HeLa) | Human | MTRF1L | 1:3~1:6 | Negative | Online Inquiry |
KO21665 | MTRF1L Knockout cell line (HCT 116) | Human | MTRF1L | 1:2~1:4 | Negative | Online Inquiry |
KO21666 | MTRF1L Knockout cell line (HEK293) | Human | MTRF1L | 1:3~1:6 | Negative | Online Inquiry |
KO21667 | MTRF1L Knockout cell line (A549) | Human | MTRF1L | 1:3~1:4 | Negative | Online Inquiry |
MTRF1L Gene Knockout Cell Lines are genetically engineered cell models specifically designed to disrupt the MTRF1L gene, which encodes a mitochondrial translation initiation factor vital for mitochondrial function and protein synthesis. These cell lines facilitate the study of gene function and its associated pathways, providing critical insights into mitochondrial biology and its role in cellular metabolism and disease.
The primary function of MTRF1L Gene Knockout Cell Lines is to enable researchers to investigate the consequences of MTRF1L disruption on mitochondrial dynamics and cellular phenotypes. The mechanism involves homologous recombination techniques to create targeted gene knockouts, allowing the analysis of various cellular processes, such as energy metabolism, apoptosis, and oxidative stress response. This particular model is invaluable for studying mitochondrial diseases and the roles of mitochondrial dysfunction in pathologies, such as neurodegenerative disorders and metabolic syndromes.
Scientifically, MTRF1L Gene Knockout Cell Lines have significant applications in both research and clinical settings. Researchers can utilize these models to elucidate the pathways involved in mitochondrial dysfunction, paving the way for the development of potential therapeutic strategies. In clinical research, these cell lines can serve as platforms for drug discovery, enabling the testing of compounds that may restore mitochondrial function or alleviate symptoms associated with mitochondrial diseases.
Compared to traditional models, MTRF1L Gene Knockout Cell Lines offer unique advantages, including specificity in targeting the gene of interest and the ability to accurately model human diseases at the cellular level. This specificity improves the relevance of experimental outcomes, facilitating high-quality data generation and interpretation.
For researchers and clinicians focused on mitochondrial research and related diseases, MTRF1L Gene Knockout Cell Lines present a critical tool that enhances understanding and therapeutic approaches. Our company brings years of expertise in developing high-quality biological products, ensuring that researchers have access to cutting-edge tools that contribute to their success in unraveling complex biological mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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