Gene: MTMR2
Official Full Name: myotubularin related protein 2provided by HGNC
Gene Summary: This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07879 | MTMR2 Knockout cell line (HeLa) | Human | MTMR2 | 1:3~1:6 | Negative | Online Inquiry |
KO07880 | MTMR2 Knockout cell line (HCT 116) | Human | MTMR2 | 1:2~1:4 | Negative | Online Inquiry |
KO07881 | MTMR2 Knockout cell line (HEK293) | Human | MTMR2 | 1:3~1:6 | Negative | Online Inquiry |
KO07882 | MTMR2 Knockout cell line (A549) | Human | MTMR2 | 1:3~1:4 | Negative | Online Inquiry |
MTMR2 Gene Knockout Cell Lines represent a significant advancement in the field of molecular biology and genetic research. These cell lines have been specifically engineered to have a targeted disruption of the MTMR2 gene, which encodes a member of the myotubularin-related protein family involved in lipid metabolism, cell signaling, and cellular homeostasis. By creating knockout models, researchers can examine the functional contributions of the MTMR2 gene, facilitating a deeper understanding of its role in various biological processes and diseases.
The primary function of MTMR2 gene knockout cell lines is to elucidate the pathways affected by the absence of the MTMR2 protein. This can be particularly relevant in the context of diseases such as Charcot-Marie-Tooth disease, where dysfunction in myotubularins has been implicated. By using these knockout cell lines, researchers can assess alterations in cellular pathways, lipid profiles, and signaling mechanisms, providing insights into disease mechanisms and potentially guiding therapeutic strategies.
The scientific importance of these cell lines lies in their application for both basic and translational research. In laboratory settings, they are invaluable for functional validation of genetic data, drug screening, and understanding gene interactions. Clinically, MTMR2 knockout models can serve as preclinical tools for investigating novel treatments or drug candidates aimed at conditions associated with MTMR2 deficiency.
One of the key advantages of our MTMR2 Gene Knockout Cell Lines is their reliability and reproducibility, which are critical in generating consistent experimental results. In contrast to alternative models, such as transient knockdowns, our stable knockout lines provide an enduring platform for long-term studies, enabling researchers to explore the effects of MTMR2 gene loss over extended periods.
The value of these cell lines for researchers and clinicians extends beyond their immediate research findings; they pave the way for potential discoveries that could lead to significant advancements in understanding and treating diseases. With our expertise in cell line development and genetic engineering, we are committed to providing high-quality biological products that empower scientists in their quest for knowledge and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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