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MTIF3 Knockout Cell Lines

Gene: MTIF3

Official Full Name: mitochondrial translational initiation factor 3provided by HGNC

Gene Summary: This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28866 MTIF3 Knockout cell line (HeLa) Human MTIF3 1:3~1:6 Negative Online Inquiry
KO28867 MTIF3 Knockout cell line (HCT 116) Human MTIF3 1:2~1:4 Negative Online Inquiry
KO28868 MTIF3 Knockout cell line (HEK293) Human MTIF3 1:3~1:6 Negative Online Inquiry
KO28869 MTIF3 Knockout cell line (A549) Human MTIF3 1:3~1:4 Negative Online Inquiry

Background

MTIF3 Gene Knockout Cell Lines are specially developed cellular models that have undergone precise genomic editing to disrupt the MTIF3 gene, which encodes a crucial mitochondrial translation initiation factor. These cell lines enable researchers to investigate the role of MTIF3 in mitochondrial function, protein synthesis, and cellular metabolism. By providing a platform that mimics the physiological conditions of specific perturbed states, these knockout models facilitate a deeper understanding of mitochondrial-related diseases as well as the cellular responses to various metabolic stressors.

The primary function of the MTIF3 knockout is to allow researchers to explore how the absence of this protein influences mitochondrial translation and subsequent cellular energetics. By employing techniques such as CRISPR-Cas9 gene editing, these cell lines exhibit precise genetic modifications which allow for comprehensive studies into the downstream effects on mitochondrial biogenesis, reactive oxygen species (ROS) production, and cellular apoptosis.

In both research and clinical settings, the MTIF3 Gene Knockout Cell Lines have profound importance; they serve as invaluable tools for drug discovery, validation of genetic therapies, and models to study conditions such as neurodegenerative diseases and metabolic disorders connected to mitochondrial dysfunction. The insights gained from these studies could pave the way for novel therapeutic approaches.

One notable advantage of these cell lines over alternative models is their specific targeting of the MTIF3 gene, allowing for a clean genetic background devoid of off-target effects often associated with more generalized knockouts. This specificity translates to enhanced reproducibility and reliability of data, which is paramount in scientific research.

Ultimately, the MTIF3 Gene Knockout Cell Lines stand as an indispensable resource for researchers and clinicians dedicated to elucidating mitochondrial biology and developing innovative treatments for mitochondrial-related pathologies. Our company’s commitment to excellence in developing high-quality biological products ensures that researchers will have access to cutting-edge tools that enhance their studies and contribute to significant scientific advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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