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MTIF2 Knockout Cell Lines

Gene: MTIF2

Official Full Name: mitochondrial translational initiation factor 2provided by HGNC

Gene Summary: During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36537 MTIF2 Knockout cell line (HeLa) Human MTIF2 1:3~1:6 Negative Online Inquiry
KO36538 MTIF2 Knockout cell line (HCT 116) Human MTIF2 1:2~1:4 Negative Online Inquiry
KO36539 MTIF2 Knockout cell line (HEK293) Human MTIF2 1:3~1:6 Negative Online Inquiry
KO36540 MTIF2 Knockout cell line (A549) Human MTIF2 1:3~1:4 Negative Online Inquiry

Background

MTIF2 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disrupt the MTIF2 gene, which plays a critical role in mitochondrial translation and cellular energy metabolism. These knockout cell lines provide researchers with a powerful tool for studying the implications of MTIF2 dysfunction in various biological processes, including mitochondrial pathology, metabolic disorders, and aging.

The primary mechanism underpinning the utility of MTIF2 Gene Knockout Cell Lines lies in their ability to mimic the loss-of-function mutations observed in numerous diseases. By eliminating the expression of the MTIF2 gene, these cell lines allow scientists to explore the downstream effects of impaired mitochondrial protein synthesis, thereby elucidating the pathways involved in energy production and cellular stress responses. This can lead to a deeper understanding of how mitochondrial dysfunction contributes to diseases like neurodegeneration, diabetes, and cancer.

In the scientific community, the importance of MTIF2 Gene Knockout Cell Lines extends into both research and clinical applications. They are vital for drug discovery efforts aimed at identifying novel therapeutic agents that target mitochondrial dysfunction. Additionally, these cell lines facilitate the assessment of potential biomarkers associated with mitochondrial diseases, enriching preclinical studies with relevant data.

Unlike alternative models that may not precisely replicate the genetic context of the MTIF2 knockout, our cell lines offer exceptional specificity and reliability, ensuring that experimental results are directly attributable to the genetic alteration. This specificity enhances the reproducibility of data, making our product indispensable for critical studies aiming at translational applications.

For researchers and clinicians looking to explore the intricate details of mitochondrial biology, our MTIF2 Gene Knockout Cell Lines represent invaluable resources. They empower the scientific community through their unique capacity to simulate pathological conditions, paving the way for innovative solutions to complex health challenges.

At the forefront of biotechnology, our company specializes in the development of advanced biological products aimed at enriching research capabilities. With a team of experts dedicated to quality and innovation, we ensure that our offerings maintain the highest standards of scientific integrity, providing researchers with tools that can enhance their findings and ultimately contribute to breakthroughs in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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