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MSN Knockout Cell Lines

Gene: MSN

Official Full Name: moesinprovided by HGNC

Gene Summary: Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01915 MSN Knockout cell line (HeLa) Human MSN 1:3~1:6 Negative Online Inquiry
KO01916 MSN Knockout cell line (HCT 116) Human MSN 1:2~1:4 Negative Online Inquiry
KO01917 MSN Knockout cell line (HEK293) Human MSN 1:3~1:6 Negative Online Inquiry
KO01918 MSN Knockout cell line (A549) Human MSN 1:3~1:4 Negative Online Inquiry

Background

MSN Gene Knockout Cell Lines are genetically modified cell lines in which the MSN gene, known to encode the protein moesin, has been selectively disrupted. This innovative product facilitates in-depth research into the roles of the moesin protein in cellular processes such as signaling, cytoskeletal dynamics, and cell morphology. By utilizing CRISPR/Cas9 or similar gene-editing technologies, these cell lines allow for precise alterations in the genome, providing a powerful tool for scientists to explore the functional implications of moesin absence in various biological contexts.

The key functions of the MSN Gene Knockout Cell Lines include enabling researchers to assess the effects of moesin deficiency on cellular behavior, interaction with extracellular matrices, and signal transduction pathways. This pioneering approach allows for the dissection of complex cellular functions and the contributions of moesin to diseases, such as cancer and developmental disorders, where altered cell shape and migration patterns are critical.

The scientific importance of these cell lines transcends basic research; they hold immense potential in translational applications within clinical settings. Their ability to model pathophysiological states and response to therapies makes them invaluable in preclinical studies and drug discovery efforts. Moreover, the insights gained from these models can help in understanding mechanisms of disease progression and identifying novel therapeutic targets.

In comparison to traditional knockdown approaches using RNA interference, the MSN Gene Knockout Cell Lines offer a permanent alteration, leading to more stable phenotypic changes that are crucial for long-term studies. Furthermore, this knockout model eliminates the off-target effects commonly associated with transient methods, resulting in more reliable data.

For researchers and clinicians focused on elucidating the complexities of cell biology, the MSN Gene Knockout Cell Lines provide a comprehensive and innovative approach that enhances experimental accuracy and supports the advancement of medical science. Our company specializes in developing high-quality biological products tailored to meet the needs of the research community, ensuring that scientists have access to robust and validated tools that foster discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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