Gene: MRPL45
Official Full Name: mitochondrial ribosomal protein L45provided by HGNC
Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24948 | MRPL45 Knockout cell line (HeLa) | Human | MRPL45 | 1:3~1:6 | Negative | Online Inquiry |
KO24949 | MRPL45 Knockout cell line (HCT 116) | Human | MRPL45 | 1:2~1:4 | Negative | Online Inquiry |
KO24950 | MRPL45 Knockout cell line (A549) | Human | MRPL45 | 1:3~1:4 | Negative | Online Inquiry |
MRPL45 Gene Knockout Cell Lines are specially designed cellular models that have had the MRPL45 gene, which encodes a mitochondrial ribosomal protein, effectively disrupted or eliminated. This innovative tool enables researchers to investigate the function of the MRPL45 gene and its implications in mitochondrial biogenesis, protein synthesis, and cellular metabolism. By creating these knockout cell lines, scientists can gain invaluable insights into the molecular pathways affected by the loss of MRPL45, providing a clearer understanding of its role in various physiological and pathological processes.
The primary mechanism of action for MRPL45 Gene Knockout Cell Lines involves the selective disruption of the gene responsible for mitochondrial ribosome assembly. Consequently, this leads to alterations in mitochondrial protein synthesis, energy production, and overall cellular homeostasis. Researchers can utilize these cell lines to explore the consequences of MRPL45 deficiencies on mitochondrial function and how these disruptions are linked to diseases such as neurodegeneration, metabolic disorders, and cancer.
In terms of scientific importance, MRPL45 Gene Knockout Cell Lines serve as an essential resource in both basic and applied research. They can facilitate drug discovery processes by uncovering metabolic vulnerabilities in cancer cells or by identifying potential therapeutic targets to mitigate mitochondrial dysfunction. In clinical settings, understanding the biological implications of MRPL45 can contribute to better diagnostic strategies and treatment approaches.
What sets MRPL45 Gene Knockout Cell Lines apart from alternative models is their precise gene editing capabilities, paired with validated control conditions. This ensures reproducibility and reliability in experimental results, which are crucial for advancing research findings. Additionally, these cell lines are versatile platforms that can be tailored to various study designs, making them indispensable for researchers aiming to delve deeper into mitochondrial biology.
For researchers and clinicians alike, the MRPL45 Gene Knockout Cell Lines represent a valuable tool that enhances the understanding of mitochondrial dynamics and their connection to human health. By leveraging this product, organizations can push the boundaries of knowledge in mitochondrial research, ultimately driving innovation in treatments and interventions. Our company, recognized for its commitment to high-quality biological products, offers these cell lines as part of a comprehensive range of genetic tools aimed at empowering scientists in their quest for breakthroughs in cellular and molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.