Gene: MPST
Official Full Name: mercaptopyruvate sulfurtransferaseprovided by HGNC
Gene Summary: This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06167 | MPST Knockout cell line (HeLa) | Human | MPST | 1:3~1:6 | Negative | Online Inquiry |
KO06168 | MPST Knockout cell line (HCT 116) | Human | MPST | 1:2~1:4 | Negative | Online Inquiry |
KO06169 | MPST Knockout cell line (HEK293) | Human | MPST | 1:3~1:6 | Negative | Online Inquiry |
KO06170 | MPST Knockout cell line (A549) | Human | MPST | 1:3~1:4 | Negative | Online Inquiry |
MPST Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the MPST gene, which encodes the enzyme mercaptopyruvate sulfurtransferase. This enzyme plays a crucial role in the metabolism of sulfur compounds and has been implicated in various biological processes, including antioxidant defense and sulfide metabolism. The knockout of this gene provides researchers with valuable insights into its function and the downstream effects of its absence on cellular physiology.
These cell lines operate on a well-established technique that employs CRISPR-Cas9 gene editing technology to achieve precise deletions in the MPST gene. By studying these knockout models, scientists can elucidate the gene's role in cellular redox balance, neuroprotective pathways, and metabolic regulation, thus advancing our understanding of physiological processes and disease mechanisms. The use of these cell lines is particularly vital in research fields such as cancer biology, neurology, and metabolic disorders, where aberrant sulfur metabolism may contribute to pathogenesis.
One of the most significant advantages of the MPST Gene Knockout Cell Lines is their ability to provide a clean and specific genetic background, allowing for highly controlled experimental conditions. Compared to alternative methods of gene disruption, such as using RNA interference, knockout cell lines offer a more permanent solution, facilitating long-term studies and reducing variability. Furthermore, these cell lines can be applied in high-throughput screening assays, making them an invaluable resource for drug discovery and functional genomics.
The value of MPST Gene Knockout Cell Lines to researchers and clinicians cannot be overstated. They enable detailed investigations into the role of MPST in various biological contexts, opening avenues for therapeutic interventions targeting this pathway. With growing interest in redox biology and its implications for human health, these cell lines represent a critical tool for advancing our understanding of complex biological systems.
As a leader in the development of innovative biological products, our company is committed to providing high-quality gene knockout models, empowering researchers to make groundbreaking discoveries. Our dedicated team of experts ensures that each product meets rigorous scientific standards, facilitating reliable and reproducible research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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