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MOCOS Knockout Cell Lines

Gene: MOCOS

Official Full Name: molybdenum cofactor sulfuraseprovided by HGNC

Gene Summary: This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16118 MOCOS Knockout cell line (HeLa) Human MOCOS 1:3~1:6 Negative Online Inquiry
KO16119 MOCOS Knockout cell line (HCT 116) Human MOCOS 1:2~1:4 Negative Online Inquiry
KO16120 MOCOS Knockout cell line (HEK293) Human MOCOS 1:3~1:6 Negative Online Inquiry
KO16121 MOCOS Knockout cell line (A549) Human MOCOS 1:3~1:4 Negative Online Inquiry

Background

MOCOS Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of gene function and validation of therapeutic targets. Utilizing CRISPR-Cas9 technology, these cell lines provide precise and efficient alteration of the MOCOS gene, which encodes for a crucial enzyme involved in various metabolic processes, particularly in the context of redox biology and mitochondrial function.

The primary mechanism by which MOCOS Gene Knockout Cell Lines operate involves the disruption of the MOCOS gene, leading to the complete loss of its protein product. This loss can significantly alter metabolic pathways, allowing researchers to investigate the biochemical and physiological implications of MOCOS deficiency in cellular models. Through the use of these knockout lines, scientists can meticulously evaluate the role of MOCOS in processes such as oxidative stress response, mitochondrial dynamics, and cellular signaling pathways.

The scientific importance of MOCOS Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they can serve as vital tools for elucidating the mechanisms of diseases linked to mitochondrial dysfunction, including neurodegenerative disorders and metabolic syndromes. Clinically, understanding the role of MOCOS may provide insights into developing targeted therapies aiming at restoring normal gene function or compensating for the loss of MOCOS activity.

Compared to traditional gene knockout methods, MOCOS Gene Knockout Cell Lines exhibit enhanced specificity and efficacy due to the precision of CRISPR-Cas9 technology. This allows for faster turnaround in experimental design and validation, making them a superior choice for researchers seeking reliable results without the complications associated with off-target effects often seen in other knockout methods.

For researchers and clinicians, the value of MOCOS Gene Knockout Cell Lines lies in their ability to provide clear, reproducible insights into gene functionality and metabolic disease mechanisms. These cell lines not only streamline experimental workflows but also offer a robust foundation for future therapeutic innovations.

At [Your Company Name], we pride ourselves on our deep biological expertise and commitment to advancing scientific discovery. Our portfolio of high-quality gene knockout models, including the MOCOS Gene Knockout Cell Lines, positions us as leaders in providing essential tools for cutting-edge research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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