Gene: MOB1B
Official Full Name: MOB kinase activator 1Bprovided by HGNC
Gene Summary: The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08573 | MOB1B Knockout cell line (HeLa) | Human | MOB1B | 1:3~1:6 | Negative | Online Inquiry |
KO08574 | MOB1B Knockout cell line (HCT 116) | Human | MOB1B | 1:2~1:4 | Negative | Online Inquiry |
KO08575 | MOB1B Knockout cell line (HEK293) | Human | MOB1B | 1:3~1:6 | Negative | Online Inquiry |
KO08576 | MOB1B Knockout cell line (A549) | Human | MOB1B | 1:3~1:4 | Negative | Online Inquiry |
MOB1B Gene Knockout Cell Lines are specialized genetically engineered cell lines designed to facilitate the study of the MOB1B gene function and its role in various cellular processes. These cell lines are created by employing CRISPR-Cas9 technology to precisely disrupt the MOB1B gene, leading to a loss-of-function phenotype. This targeted knockout allows researchers to investigate the downstream effects of MOB1B deletion on cellular signaling, proliferation, and metabolic pathways, thus providing a deeper understanding of its biological relevance.
The primary mechanism of action for the MOB1B Gene Knockout Cell Lines involves the disruption of the protein interactions that MOB1B typically mediates, particularly within the Hippo signaling pathway. This pathway is crucial for regulating cell growth, differentiation, and apoptosis; therefore, studying these knockout cell lines can shed light on tumorigenesis and other pathological conditions. These models serve as invaluable tools for elucidating gene function and offer insights into the molecular mechanisms underlying diseases such as cancer and metabolic disorders.
From a scientific standpoint, these cell lines are instrumental in both basic research and clinical applications. They enable drug discovery efforts and the validation of therapeutic targets, providing a robust platform for screening potential anti-cancer compounds or other pharmacological agents. Moreover, they allow for high-throughput analyses, enhancing research productivity and efficiency.
What sets our MOB1B Gene Knockout Cell Lines apart from other alternatives is their precise genetic modification and extensive characterization, ensuring high reproducibility and reliability of results. Furthermore, they come with comprehensive supporting data that elucidate their biological context, reducing time spent on initial validation.
Researchers and clinicians alike will find great value in the MOB1B Gene Knockout Cell Lines as they advance the understanding of gene function and facilitate the development of novel therapeutic strategies. By leveraging our expertise in genetic engineering and cell line development, our company is committed to providing top-tier biological products that support and enhance scientific research initiatives in the field of molecular biology and beyond.
Please note that all services are for research use only. Not intended for any clinical use.
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