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MINK1 Knockout Cell Lines

Gene: MINK1

Official Full Name: misshapen like kinase 1provided by HGNC

Gene Summary: This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23427 MINK1 Knockout cell line (HeLa) Human MINK1 1:3~1:6 Negative Online Inquiry
KO23428 MINK1 Knockout cell line (HCT 116) Human MINK1 1:2~1:4 Negative Online Inquiry
KO23429 MINK1 Knockout cell line (HEK293) Human MINK1 1:3~1:6 Negative Online Inquiry
KO23430 MINK1 Knockout cell line (A549) Human MINK1 1:3~1:4 Negative Online Inquiry

Background

MINK1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the Mitogen-Activated Protein Kinase Interacting Kinase 1 (MINK1) gene, which plays a critical role in various signaling pathways, including those involved in cellular stress response and mitogen-activated protein kinase (MAPK) signaling. These knockout cell lines provide a unique platform for researchers to study the functional consequences of MINK1 depletion, allowing for a better understanding of its role in cell proliferation, differentiation, and apoptosis.

The primary function of MINK1 involves the regulation of MAPK pathways, which are essential for transmitting extracellular signals to elicit appropriate cellular responses. By utilizing MINK1 Knockout Cell Lines, researchers can ascertain how the absence of this kinase influences cellular behavior and contributes to disease pathology, such as cancer progression or neurodegenerative disorders. The precise genetic modification ensures reproducibility and reliability in experiments, facilitating high-quality data generation.

In terms of scientific importance, these knockout cell lines are invaluable in research settings focused on signal transduction and therapeutic target identification. They serve as a robust tool for drug discovery, toxicity testing, and elucidating the mechanisms of disease. Their application in clinical research could uncover novel therapeutic strategies aimed at diseases linked to dysregulated MAPK signaling.

Compared to conventional methods such as chemical inhibition or overexpression systems, MINK1 Gene Knockout Cell Lines offer a more straightforward and stable approach to dissecting gene function due to the permanent nature of the genetic modification. This stability reduces variability, providing more consistent experimental outcomes, which is essential for drawing reliable conclusions.

Researchers and clinicians are encouraged to incorporate MINK1 Gene Knockout Cell Lines into their studies to enhance the depth and breadth of their investigations, particularly in areas where MINK1 signaling has been implicated. This product not only drives innovation in the laboratory but also enriches the global scientific community by enabling pathway insights that could lead to groundbreaking therapies.

Through years of expertise and dedication to developing advanced biological research tools, our company stands as a leader in delivering high-quality, rigorously validated cell lines, including the MINK1 Gene Knockout Cell Lines, thereby supporting the scientific endeavors of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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