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MIB1 Knockout Cell Lines

Gene: MIB1

Official Full Name: MIB E3 ubiquitin protein ligase 1provided by HGNC

Gene Summary: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16186 MIB1 Knockout cell line (HeLa) Human MIB1 1:3~1:6 Negative Online Inquiry
KO16187 MIB1 Knockout cell line (HCT 116) Human MIB1 1:2~1:4 Negative Online Inquiry
KO16188 MIB1 Knockout cell line (HEK293) Human MIB1 1:3~1:6 Negative Online Inquiry
KO16189 MIB1 Knockout cell line (A549) Human MIB1 1:3~1:4 Negative Online Inquiry

Background

MIB1 Gene Knockout Cell Lines are genetically engineered cell lines designed to selectively disrupt the MIB1 gene, which encodes for the Mind Bomb 1 protein, a crucial player in the Notch signaling pathway. This product facilitates the study of MIB1's role in cellular processes, including epithelial differentiation and cellular proliferation. By employing CRISPR-Cas9 technology, these knockout cell lines allow researchers to achieve precise gene editing, enabling the observation of phenotypic changes as a result of gene knockout.

The primary function of MIB1 Gene Knockout Cell Lines is to provide an experimental platform for dissecting the multifaceted roles of MIB1 in various biological contexts. MIB1 has been implicated in oncogenesis, neurogenesis, and immune responses, making these cell lines particularly valuable for studies in cancer research, developmental biology, and regenerative medicine. Researchers can use these models to explore gene function, identify potential therapeutic targets, and evaluate the effects of drug treatments that interact with the Notch signaling pathway.

Compared to conventional gene knockout methods, MIB1 Gene Knockout Cell Lines offer a streamlined and efficient approach that reduces off-target effects, thus increasing experimental reliability. Unlike other cell models, these knockout lines will enable researchers to generate consistently reproducible results, providing a more accurate reflection of in vivo biological functions.

For scientists and clinicians alike, understanding the implications of MIB1 in disease mechanisms can lead to novel interventions and therapeutic strategies. The MIB1 Gene Knockout Cell Lines empower researchers to unlock new insights, advance their investigations effectively, and enhance their experimental outcomes.

Our company specializes in providing high-quality biological products and innovative solutions tailored to the needs of the research community. With a commitment to excellence and reliability, we offer a diverse portfolio of genetically modified cell lines that support groundbreaking discoveries across multiple fields of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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