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MFF Knockout Cell Lines

Gene: MFF

Official Full Name: mitochondrial fission factorprovided by HGNC

Gene Summary: This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20719 MFF Knockout cell line (HeLa) Human MFF 1:3~1:6 Negative Online Inquiry
KO20720 MFF Knockout cell line (HCT 116) Human MFF 1:2~1:4 Negative Online Inquiry
KO20721 MFF Knockout cell line (HEK293) Human MFF 1:3~1:6 Negative Online Inquiry
KO20722 MFF Knockout cell line (A549) Human MFF 1:3~1:4 Negative Online Inquiry

Background

MFF Gene Knockout Cell Lines are a cutting-edge tool in molecular biology that enable researchers to investigate the functional role of the MFF gene (Mitochondrial fission factor) in various biological processes. These cell lines are engineered using advanced CRISPR-Cas9 technology to create precise deletions in the MFF gene, allowing for the study of its impact on mitochondrial dynamics, cellular metabolism, and apoptosis.

The key functions of MFF gene knockout cells center around their ability to elucidate the mechanisms by which mitochondrial fission contributes to cell survival and differentiation. By disrupting the MFF gene, researchers can observe changes in mitochondrial shape, quantity, and functionality, offering insights into how alterations in these parameters can affect cell physiology and pathology. This application is particularly significant in understanding conditions such as neurodegeneration, metabolic disorders, and cancers, where mitochondrial dysfunction plays a critical role.

The scientific importance of these knockout cell lines extends to their utility in both research and clinical settings. They serve as invaluable models for evaluating therapeutic strategies targeting mitochondrial-related diseases, providing a platform for drug discovery and the understanding of cellular pathways influenced by mitochondrial dynamics. Furthermore, their use in high-throughput screening can accelerate the identification of novel compounds that may restore normal mitochondrial function.

What sets our MFF Gene Knockout Cell Lines apart from alternative models is their high fidelity and specificity in gene editing, coupled with streamlined culture protocols that reduce experimental variability. This ensures robust, reproducible results, making them an ideal choice for rigorous scientific studies. Our advanced validation processes guarantee that each cell line maintains the characteristic profiles necessary for accurate experimental interpretation.

Researchers, clinicians, and pharmaceutical companies will find significant value in our MFF Gene Knockout Cell Lines as they provide reliable insight into mitochondrial biology and its implications for health and disease. By harnessing our innovative cell lines, users can enhance their understanding of the intricate connections between mitochondrial function and cellular health.

With a proven track record in providing top-tier biological products, our company is dedicated to fostering scientific advancements. We continue to support researchers and clinicians alike, offering cutting-edge tools and expertise that drive innovative discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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