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MEF2D Knockout Cell Lines

Gene: MEF2D

Official Full Name: myocyte enhancer factor 2Dprovided by HGNC

Gene Summary: This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09428 MEF2D Knockout cell line (HeLa) Human MEF2D 1:3~1:6 Negative Online Inquiry
KO09429 MEF2D Knockout cell line (HCT 116) Human MEF2D 1:2~1:4 Negative Online Inquiry
KO09430 MEF2D Knockout cell line (HEK293) Human MEF2D 1:3~1:6 Negative Online Inquiry
KO09431 MEF2D Knockout cell line (A549) Human MEF2D 1:3~1:4 Negative Online Inquiry

Background

MEF2D Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the MEF2D gene, which encodes a member of the MEF2 family of transcription factors. These cell lines serve as invaluable tools for researchers investigating the role of MEF2D in various biological processes, including muscle development, neuronal differentiation, and immune responses. The knockout mechanism is achieved through advanced genome editing technologies, such as CRISPR-Cas9, which enable precise modifications by inducing double-strand breaks in the target DNA, leading to insertion or deletion mutations that disrupt gene function.

The scientific importance of MEF2D Gene Knockout Cell Lines extends to both academic research and clinical applications. By studying these cell lines, researchers can elucidate the pathways regulated by MEF2D and its implications in diseases like cancer, heart disease, and neurodegenerative disorders. These models allow for high-throughput screening of potential therapeutic compounds, as well as in-depth studies on gene expression and cellular behavior in the absence of MEF2D.

This product offers distinct advantages over traditional knockdown models, such as siRNA or shRNA, as knockout cell lines provide a permanent and stable solution for gene disruption. Researchers benefit from the robustness and reliability of these lines, offering consistent results across experiments. Furthermore, our MEF2D Gene Knockout Cell Lines are meticulously validated for quality and functionality, ensuring that they meet the rigorous standards required for cutting-edge research.

In summary, these cell lines are essential for researchers and clinicians seeking to deepen their understanding of MEF2D's role in health and disease. By providing a reliable tool for genetic investigation, we empower advancements in therapeutic development and disease modeling. Our company prides itself on its expertise in creating high-quality biological products, thereby supporting the research community with innovative solutions that drive scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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