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MBNL1 Knockout Cell Lines

Gene: MBNL1

Official Full Name: muscleblind like splicing regulator 1provided by HGNC

Gene Summary: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00145 MBNL1 Knockout cell line (Vips) Human MBNL1 Negative Online Inquiry
KO06051 MBNL1 Knockout cell line (HeLa) Human MBNL1 1:3~1:6 Negative Online Inquiry
KO06052 MBNL1 Knockout cell line (HCT 116) Human MBNL1 1:2~1:4 Negative Online Inquiry
KO06053 MBNL1 Knockout cell line (HEK293) Human MBNL1 1:3~1:6 Negative Online Inquiry
KO06054 MBNL1 Knockout cell line (A549) Human MBNL1 1:3~1:4 Negative Online Inquiry

Background

MBNL1 Gene Knockout Cell Lines represent a significant advancement in genetic research, specifically engineered to disable the MBNL1 gene, which plays a crucial role in various cellular processes such as RNA splicing and gene regulation. These knockout cell lines are created through precise genome editing techniques, such as CRISPR/Cas9, leading to the targeted disruption of the MBNL1 coding sequence. As a result, they provide researchers with a vital tool to investigate the gene's impact on cellular physiology and disease mechanisms.

The primary function of MBNL1 Gene Knockout Cell Lines is to facilitate the study of MBNL1's role in health and disease. By observing changes in cellular behavior, gene expression profiles, and metabolic pathways in the absence of MBNL1, researchers can gain insights into its contributions to muscle disorders, neurodegenerative diseases, and various other pathologies. The ability to conduct loss-of-function studies in a controlled environment allows for a better understanding of potential therapeutic targets and biomarkers.

In terms of scientific importance, MBNL1 knockout models are essential in both basic and applied research settings, enabling the exploration of alternative splicing events associated with disease states. They serve as critical platforms for drug discovery and validation, providing a reliable means to assess therapeutic interventions aimed at modulating MBNL1-related pathways.

Compared to alternative models, such as wild-type cell lines or other gene knockout systems, MBNL1 Gene Knockout Cell Lines present unique advantages, including high specificity and reproducibility in experimental results. The targeted knockout reduces off-target effects, thus increasing the reliability of experimental findings.

For researchers and clinicians focused on understanding the complexities of gene function and the mechanisms behind genetic diseases, MBNL1 Gene Knockout Cell Lines are invaluable. They offer not only a model for dissecting the biological roles of MBNL1 but also an opportunity to develop novel therapeutics aimed at diseases where MBNL1 dysregulation is evident.

Our company prides itself on delivering high-quality biological products backed by extensive expertise in genetic engineering techniques. With our MBNL1 Gene Knockout Cell Lines, researchers can be confident in accessing reliable models that enhance their studies and contribute significantly to the advancement of genetic research.

Please note that all services are for research use only. Not intended for any clinical use.

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