Gene: MATN3
Official Full Name: matrilin 3provided by HGNC
Gene Summary: This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04778 | MATN3 Knockout cell line (HeLa) | Human | MATN3 | 1:3~1:6 | Negative | Online Inquiry |
KO04779 | MATN3 Knockout cell line (A549) | Human | MATN3 | 1:3~1:4 | Negative | Online Inquiry |
MATN3 Gene Knockout Cell Lines are an advanced biological tool developed for researchers aiming to investigate the specific functions of the MATN3 gene, which encodes a key component of the extracellular matrix in various tissues. By engineering these cell lines to lack the expression of the MATN3 protein, scientists can explore the gene's role in cellular processes such as adhesion, proliferation, and differentiation, illuminating its significance in health and disease.
The fundamental mechanism of MATN3 knockout cell lines centers around the complete removal of the MATN3 gene using CRISPR-Cas9 technology, ensuring precise and efficient gene disruption. This allows researchers to create controlled environments for studying the cellular and molecular pathways affected by MATN3 deficiency. Importantly, these cell lines serve as crucial models for understanding conditions such as musculoskeletal disorders and certain cancers where the extracellular matrix plays a pivotal role.
Scientifically, the MATN3 Gene Knockout Cell Lines have vast applications in both fundamental research and potential clinical settings, including drug discovery and regenerative medicine. Their ability to provide insights into gene function, cellular signaling, and tissue development makes them invaluable for developing targeted therapies and understanding pathological mechanisms.
One of the key advantages of these cell lines is their reliability and reproducibility, which enhances the validity of experimental results when compared to alternative in vitro models such as primary cell cultures or RNA-interfered cells. Furthermore, our cell lines come with extensive characterization data and assay-ready formats, allowing for streamlined experimental design and reduced time in preliminary optimization.
For researchers and clinicians, the MATN3 Gene Knockout Cell Lines represent a powerful resource for advancing knowledge in cell biology and therapeutic development. Their unique capabilities facilitate an enriched understanding of gene function, ultimately driving innovations in the treatment of relevant diseases.
We pride ourselves on our extensive expertise in the field of genetic materials and cell line development, offering high-quality biological products that empower the scientific community to make breakthroughs in research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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