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MAST3 Knockout Cell Lines

Gene: MAST3

Official Full Name: microtubule associated serine/threonine kinase 3provided by HGNC

Gene Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to be located in cytoplasm. Implicated in developmental and epileptic encephalopathy 108. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29988 MAST3 Knockout cell line (HeLa) Human MAST3 1:3~1:6 Negative Online Inquiry
KO29989 MAST3 Knockout cell line (HCT 116) Human MAST3 1:2~1:4 Negative Online Inquiry
KO29990 MAST3 Knockout cell line (HEK293) Human MAST3 1:3~1:6 Negative Online Inquiry
KO29991 MAST3 Knockout cell line (A549) Human MAST3 1:3~1:4 Negative Online Inquiry

Background

MAST3 Gene Knockout Cell Lines are genetically modified cell lines specifically designed for the study of the Microtubule Associated Serine/Threonine Kinase 3 (MAST3), a kinase involved in various cellular processes including cell proliferation, differentiation, and survival. By utilizing CRISPR-Cas9 technology, these cell lines have had the MAST3 gene precisely disrupted, facilitating investigations into its function and role within different biological contexts.

The primary mechanism of action for these cell lines lies in the complete ablation of MAST3 expression, allowing researchers to observe the phenotypic changes that occur in its absence. This enables the elucidation of MAST3's involvement in critical pathways such as cell cycle regulation, apoptosis, and development—domains increasingly recognized for their relevance to cancer biology and neurodegenerative diseases. Additionally, the knockout model serves as an invaluable tool for assessing the potential of MAST3 as a therapeutic target.

Scientifically, the MAST3 Gene Knockout Cell Lines provide unique insights into signaling pathways and cellular responses that could be pivotal in drug discovery and therapeutic strategies. Compared to traditional wild-type models, these knockout lines afford a clearer picture of the specific impacts of MAST3 inhibition, thus offering a more focused approach to investigating its biological functions. Furthermore, with the precise genetic modification, these cell lines minimize the off-target effects often associated with previous genetic manipulation techniques, enhancing experimental reliability.

For researchers and clinicians, the ability to leverage these knockout lines translates into significantly improved experimental outcomes, paving the way for groundbreaking discoveries in the mechanisms of disease and potential therapeutic interventions. Our company prides itself on its commitment to delivering high-quality, state-of-the-art biological products tailored to advance biological research. With a team of experts in genetic engineering and cell biology, we ensure that our offerings align with the latest scientific advancements, supporting our clientele in their pursuit of impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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