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MAST1 Knockout Cell Lines

Gene: MAST1

Official Full Name: microtubule associated serine/threonine kinase 1provided by HGNC

Gene Summary: This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30062 MAST1 Knockout cell line (HeLa) Human MAST1 1:3~1:6 Negative Online Inquiry
KO30063 MAST1 Knockout cell line (HCT 116) Human MAST1 1:2~1:4 Negative Online Inquiry
KO30064 MAST1 Knockout cell line (HEK293) Human MAST1 1:3~1:6 Negative Online Inquiry
KO30065 MAST1 Knockout cell line (A549) Human MAST1 1:3~1:4 Negative Online Inquiry

Background

MAST1 Gene Knockout Cell Lines are precisely engineered cellular models designed to study the function of the MAST1 gene through targeted disruption. The MAST1 gene encodes a member of the microtubule-associated serine/threonine kinase family, which has been implicated in various cellular processes, including cell proliferation, survival, and motility. By creating knockout cell lines, researchers can investigate the specific roles and pathways associated with MAST1, allowing for a deeper understanding of its physiological and pathological implications.

These cell lines function on the principle of CRISPR/Cas9 gene-editing technology, which enables the targeted deletion of the MAST1 gene. This results in the ablation of its protein product, facilitating the study of gene function in both in vitro and in vivo environments. By assessing the phenotypic effects resulting from MAST1 knockout, researchers can delineate its role in cancer progression, neurodegenerative diseases, and other conditions where microtubule dynamics are crucial.

The scientific importance of MAST1 Gene Knockout Cell Lines extends to numerous research applications, including drug discovery, functional genomics, and cellular signaling studies. In clinical settings, understanding MAST1 function could lead to the development of targeted therapies for diseases where its dysregulation is evident, thus enhancing personalized medicine approaches.

One of the distinctive advantages of our MAST1 Gene Knockout Cell Lines is the validated efficiency and specificity of the CRISPR/Cas9 system employed. Unlike traditional knockdown methodologies that may leave residual gene expression, these knockout lines offer a complete absence of MAST1 function, allowing for clearer insights into gene mechanisms. Additionally, our cell lines come with comprehensive experimental protocols and characterization data, streamlining research workflows and increasing reliability.

For researchers and clinicians aiming to explore the nuances of gene functionality and its implications in health and disease, MAST1 Gene Knockout Cell Lines represent a valuable resource. The precision and rigor of our product ensure that users can generate reproducible and impactful results. With extensive experience in biological product development and commitment to advancing scientific research, our company stands as a leading provider of innovative solutions tailored to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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