Gene: MARK4
Official Full Name: microtubule affinity regulating kinase 4provided by HGNC
Gene Summary: This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16325 | MARK4 Knockout cell line (HeLa) | Human | MARK4 | 1:3~1:6 | Negative | Online Inquiry |
KO16326 | MARK4 Knockout cell line (HCT 116) | Human | MARK4 | 1:2~1:4 | Negative | Online Inquiry |
KO16327 | MARK4 Knockout cell line (HEK293) | Human | MARK4 | 1:3~1:6 | Negative | Online Inquiry |
KO16328 | MARK4 Knockout cell line (A549) | Human | MARK4 | 1:3~1:4 | Negative | Online Inquiry |
MARK4 Gene Knockout Cell Lines are a specialized set of advanced biological tools designed for the in-depth study of the MARK4 (Microtubule Affinity-Regulating Kinase 4) gene's role in cellular processes. These cell lines have been engineered to exhibit a complete knockout of the MARK4 gene, facilitating precise investigation of its physiological and pathological functions. By eliminating the expression of MARK4, researchers can effectively dissect the mechanisms underlying cell proliferation, differentiation, and apoptosis, as well as the kinase's involvement in various diseases, particularly cancer.
The key functions of MARK4 Gene Knockout Cell Lines lie in their ability to help elucidate the downstream signaling pathways that are influenced by MARK4. When the MARK4 gene is absent, researchers can observe changes in cellular behavior, including alterations in microtubule dynamics, cell migration, and responses to growth factors. This functional impairment is vital for understanding how MARK4 contributes to tumorigenesis and other malignancies. The ability to study these altered phenotypes in a controlled environment enhances the potential for developing targeted therapeutic strategies.
The scientific importance of MARK4 Gene Knockout Cell Lines extends to both fundamental research and translational applications. These cell lines serve as valuable models for studying the role of MARK4 in various biological contexts, including cellular motility, and neurodegenerative diseases. In clinical settings, they provide insights that could lead to novel biomarker identification or therapeutic targets, making them indispensable for cancer research and beyond.
Unlike conventional wild-type cell lines, which may contain variable expressions of genes, the MARK4 Gene Knockout Cell Lines provide a consistent and replicable platform that guarantees precise experimental conditions. This specificity enhances reproducibility and reliability in research findings, which is essential for validation and application in clinical hypotheses. Additionally, these knockout lines serve as powerful tools for drug screening and mechanism-of-action studies of potential anti-cancer agents.
Researchers and clinicians, particularly those focused on oncology and cell biology, will find great value in incorporating MARK4 Gene Knockout Cell Lines into their experimental repertoire. With these cell lines, users gain an unparalleled opportunity to decipher the complexities of MARK4 biology and its implications for human health.
Our company is dedicated to advancing scientific discoveries by providing high-quality biological products tailored for research excellence. We pride ourselves on our expertise in genetic engineering and offer a range of innovative tools designed to propel researchers toward groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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