Home / MARCKS Knockout Cell Lines

MARCKS Knockout Cell Lines

Gene: MARCKS

Official Full Name: myristoylated alanine rich protein kinase C substrateprovided by HGNC

Gene Summary: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36744 MARCKS Knockout cell line (HeLa) Human MARCKS 1:3~1:6 Negative Online Inquiry
KO36745 MARCKS Knockout cell line (HCT 116) Human MARCKS 1:2~1:4 Negative Online Inquiry
KO36746 MARCKS Knockout cell line (HEK293) Human MARCKS 1:3~1:6 Negative Online Inquiry
KO36747 MARCKS Knockout cell line (A549) Human MARCKS 1:3~1:4 Negative Online Inquiry

Background

MARCKS Gene Knockout Cell Lines are specialized cell lines engineered to eliminate the expression of the MARCKS gene (myristoylated alanine-rich C kinase substrate), which plays a crucial role in regulating cellular signaling pathways. These knockout cell lines are generated using cutting-edge genome-editing technologies, such as CRISPR/Cas9, to provide researchers with precise models that mimic the biological effects associated with MARCKS absence. By creating these specific cellular environments, scientists can delve into the gene's functional contributions to processes such as cell motility, proliferation, and signal transduction, which are fundamental to developmental biology and cancer research.

The primary function of MARCKS is to modulate actin filament dynamics and cellular morphology through its interaction with calmodulin and other proteins involved in signal transduction. By knocking out the MARCKS gene, researchers can investigate the downstream effects of its loss, which can yield valuable insights into the mechanisms underlying various pathophysiological conditions. This ability to explore gene function in real-time is essential for advancing our understanding of diseases and developing new therapeutic strategies.

In scientific research and clinical applications, MARCKS Gene Knockout Cell Lines are invaluable for studying signal pathways altered in cancer, neurodegenerative diseases, and inflammatory responses. These models provide a backyard for drug discovery and therapeutic assessments, paving the way for innovative treatment options that could significantly improve patient outcomes.

Unlike other available models, the MARCKS Gene Knockout Cell Lines offer unparalleled specificity and reproducibility, allowing for precise experimental manipulations. This level of control empowers researchers to achieve more accurate results when conducting analyses or drug testing, positioning these cell lines as a superior alternative to traditional models.

For researchers, clinicians, and biotechnology professionals, the MARCKS Gene Knockout Cell Lines represent a critical tool in the advancement of molecular and cellular biology. Their integration into research protocols can lead to a deeper understanding of cellular mechanisms, enhancing experimental outcomes and driving discovery. Our company has a strong track record in producing high-quality biological products, ensuring that you receive reliable, reproducible models essential for your research success.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.