Gene: MAPRE1
Official Full Name: microtubule associated protein RP/EB family member 1provided by HGNC
Gene Summary: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30127 | MAPRE1 Knockout cell line (HeLa) | Human | MAPRE1 | 1:3~1:6 | Negative | Online Inquiry |
KO30128 | MAPRE1 Knockout cell line (HCT 116) | Human | MAPRE1 | 1:2~1:4 | Negative | Online Inquiry |
KO30129 | MAPRE1 Knockout cell line (HEK293) | Human | MAPRE1 | 1:3~1:6 | Negative | Online Inquiry |
KO30130 | MAPRE1 Knockout cell line (A549) | Human | MAPRE1 | 1:3~1:4 | Negative | Online Inquiry |
MAPRE1 Gene Knockout Cell Lines represent a groundbreaking tool in genetic research and functional genomics, specifically designed to facilitate the study of the MAPRE1 gene, which encodes a protein involved in microtubule stabilization and cellular signaling pathways. These knockout cell lines are generated using advanced CRISPR-Cas9 technology, allowing for precise and efficient disruption of the MAPRE1 gene, enabling researchers to investigate its biological functions and implications in various diseases, such as cancer and neurodegenerative disorders.
The key function of MAPRE1 gene knockout cell lines lies in their ability to provide a model system that mimics the loss of MAPRE1 protein expression. This allows for the dissection of the gene's role in cellular processes such as mitotic spindle formation, cell motility, and signal transduction mechanisms. By studying these knockout models, scientists can better understand the molecular pathways affected by MAPRE1 depletion, facilitating the identification of potential therapeutic targets.
The scientific importance of MAPRE1 gene knockout cell lines extends into both research and clinical settings. In research, they serve as invaluable tools for elucidating the contributions of MAPRE1 to cellular homeostasis and its involvement in pathophysiological conditions. Clinically, the insights gained from these models can guide the development of novel treatments, offering the potential to target pathways disrupted by MAPRE1 dysfunction.
One significant advantage of MAPRE1 gene knockout cell lines over alternatives, such as RNA interference models, is their permanence and stability. Knockout models allow for sustained examination of phenotypic changes without the temporal variability often associated with transient knockdowns. Furthermore, the ability to generate multiple knockout clones tailored to different experimental needs ensures versatility in research applications.
Researchers and clinicians alike will find MAPRE1 gene knockout cell lines to be a valuable asset in their quest to unravel the complexities of cellular functions and disease mechanisms. These models not only enhance understanding but also offer a foundation for innovative therapeutic strategies directed at MAPRE1-associated conditions.
With a commitment to delivering high-quality biological products, our company harnesses cutting-edge technologies and expertise in molecular biology to provide researchers with the tools necessary to facilitate groundbreaking discoveries in genomics and cell biology.
Please note that all services are for research use only. Not intended for any clinical use.
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