Gene: MAP3K11
Official Full Name: mitogen-activated protein kinase kinase kinase 11provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10706 | MAP3K11 Knockout cell line (HeLa) | Human | MAP3K11 | 1:3~1:6 | Negative | Online Inquiry |
KO10707 | MAP3K11 Knockout cell line (HCT 116) | Human | MAP3K11 | 1:2~1:4 | Negative | Online Inquiry |
KO10708 | MAP3K11 Knockout cell line (HEK293) | Human | MAP3K11 | 1:3~1:6 | Negative | Online Inquiry |
KO10709 | MAP3K11 Knockout cell line (A549) | Human | MAP3K11 | 1:3~1:4 | Negative | Online Inquiry |
MAP3K11 Gene Knockout Cell Lines are specialized cell models engineered to lack the MAP3K11 gene, which encodes a member of the mitogen-activated protein kinase (MAPK) signaling pathway. This product allows for the investigation of MAP3K11's role in cellular processes such as proliferation, differentiation, and apoptosis, providing researchers with vital insights into the gene's function in both normal physiology and pathological conditions.
The primary mechanism by which these knockout cell lines operate involves the absence of MAP3K11 protein production. This disruption can lead to altered signaling cascades, particularly in pathways associated with stress responses and cell survival, enabling scientists to understand the implications of MAP3K11 gene function thoroughly. By utilizing these cell lines in experimental settings, researchers can delineate the specific contributions of MAP3K11 to diseases such as cancer, neurodegeneration, and inflammatory disorders.
The scientific importance of MAP3K11 Gene Knockout Cell Lines lies in their potential applications in both basic research and clinical development. They can be used for high-throughput screening of drug candidates, elucidating signaling pathways, and developing targeted therapies aimed at related diseases. Compared to alternatives such as wild-type cell lines, knockout models provide robust tools for functional studies, enabling clearer interpretations of genetic contributions to cellular behavior.
The specific advantages of MAP3K11 Gene Knockout Cell Lines include their high specificity, reproducibility, and the ability to model loss-of-function scenarios that mimic the conditions often found in human disease. Their establishment allows for a more profound understanding of therapeutic targets, increasing the efficiency of drug development projects.
This product offers significant value to researchers and clinicians who seek to expand their understanding of signaling pathways and their implications in human health. With our commitment to excellence and innovation, [Your Company Name] leverages extensive expertise in developing biological products that empower scientific research and advance therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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