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MAGEA4 Knockout Cell Lines

Gene: MAGEA4

Official Full Name: MAGE family member A4provided by HGNC

Gene Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00082 MAGEA4 gRNA1-gRNA2 KO plasmid MAGEA4 $850
KO00733 MAGEA4 Knockout cell line(A-375) Human MAGEA4 1:3~1:4 Negative Online Inquiry

Background

MAGEA4 Gene Knockout Cell Lines are specifically designed cellular models that have undergone targeted gene disruption to eliminate the expression of the melanoma-associated antigen 4 (MAGEA4) gene. This technology utilizes advanced CRISPR-Cas9 genome-editing techniques to create a reliable platform for studying the biological functions of MAGEA4, which is recognized for its role in tumor development and immune evasion in melanoma and other cancers.

The primary function of MAGEA4 Gene Knockout Cell Lines is to provide researchers with a tool for investigating the mechanisms by which MAGEA4 influences tumor cell proliferation, differentiation, and apoptosis. By examining the phenotypic changes in these knockout lines compared to their wild-type counterparts, scientists can elucidate the gene’s regulatory pathways and its interactions within the tumor microenvironment. This data is invaluable for developing targeted therapies and understanding the broader implications of MAGEA4 in cancer immunology.

The scientific importance of these cell lines is underscored by their applications in preclinical research, drug development, and biomarker discovery. They enable detailed studies of immune responses against MAGEA4-expressing tumors, facilitating the advancement of immunotherapies. Furthermore, by providing a stable system for functional assays and high-throughput screening, these knockout cell lines accelerate the pace of research while maintaining reproducibility and consistency.

What sets MAGEA4 Gene Knockout Cell Lines apart from existing alternatives is their precision and adaptability. Unlike traditional techniques that may yield variable results, our knockout cells ensure a complete and specific gene disruption, which enhances experimental reliability. Additionally, these cell lines are compatible with various assay formats, including genomic and proteomic analyses.

For researchers and clinicians, the ability to conduct targeted investigations on MAGEA4 without the confounding variables found in non-knockout systems is a game-changer. It not only streamlines the research process but also provides clarity in data interpretation, making it easier to develop strategies for targeted therapy.

Our company's expertise in developing state-of-the-art biological tools underpins our commitment to providing products that drive innovation in scientific research. With rigorous quality assurance protocols and a focus on customer support, we ensure that our MAGEA4 Gene Knockout Cell Lines meet the highest standards in the industry, empowering researchers to make breakthroughs in cancer therapy and immunology.

Please note that all services are for research use only. Not intended for any clinical use.

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