Gene: M6PR
Official Full Name: mannose-6-phosphate receptor, cation dependentprovided by HGNC
Gene Summary: This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00597 | M6PR Knockout cell line(293T) | Human | M6PR | 1:3~1:6 | Negative | Online Inquiry |
KO07381 | M6PR Knockout cell line (HeLa) | Human | M6PR | 1:3~1:6 | Negative | Online Inquiry |
KO07382 | M6PR Knockout cell line (HCT 116) | Human | M6PR | 1:2~1:4 | Negative | Online Inquiry |
KO07383 | M6PR Knockout cell line (HEK293) | Human | M6PR | 1:3~1:6 | Negative | Online Inquiry |
KO07384 | M6PR Knockout cell line (A549) | Human | M6PR | 1:3~1:4 | Negative | Online Inquiry |
M6PR Gene Knockout Cell Lines are highly specialized cell lines developed through targeted gene editing techniques to disrupt the expression of the mannose-6-phosphate receptor (M6PR). This receptor is crucial for the intracellular trafficking of lysosomal enzymes. By knocking out the M6PR gene, these cell lines serve as an invaluable tool for studying the mechanisms of lysosomal function, protein sorting, and cellular metabolism.
The primary function of M6PR Gene Knockout Cell Lines lies in their ability to elucidate the role of M6PR in various cellular processes. When M6PR is inactivated, researchers can observe downstream effects on lysosomal enzyme activity, pathway signaling, and the consequent implications for cellular homeostasis and disease. This mechanistic insight is vital for understanding lysosomal storage disorders, which can result from impaired M6PR function.
The scientific importance of these cell lines extends to both research and clinical applications. In research settings, they enable scientists to model lysosomal dysfunction accurately, which is crucial for drug discovery and therapeutic interventions. Clinically, understanding the aberrations caused by M6PR disruption could lead to targeted therapies for diseases linked with lysosomal abnormalities, such as Gaucher disease or Fabry disease.
What sets M6PR Gene Knockout Cell Lines apart from competitors is their rigorous validation process, ensuring consistency and reliability in experimental results. Additionally, they are compatible with various high-throughput screening methods, making them a practical choice for large-scale studies.
For researchers and clinicians, these cell lines are a critical resource, providing insights that can drive innovation in therapeutic development. With our company’s expertise in genetic engineering and cell biology, M6PR Gene Knockout Cell Lines are backed by a commitment to excellence and reliability in biological product offerings, making them an essential addition to any laboratory focused on lysosomal research and therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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