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Lrpprc Knockout Cell Lines

Gene: Lrpprc

Official Full Name: leucine-rich PPR-motif containingprovided by MGI

Gene Summary: Enables RNA binding activity and single-stranded DNA binding activity. Acts upstream of or within negative regulation of mitochondrial RNA catabolic process and regulation of mitochondrial translation. Located in mitochondrion and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; genitourinary system; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00361 Lrpprc gRNA2 KO plasmid Lrpprc $850
KO01150 Lrpprc Knockout cell line(CT26.WT) Mouse Lrpprc 1:3~1:4 Negative Online Inquiry
KO01172 Lrpprc Knockout cell line (MC38) Mouse Lrpprc 1:2-1:4 Negative Online Inquiry

Background

Lrpprc Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the LRPPRC (Leucine-Rich Pentatricopeptide Repeat-Containing) gene. This gene is crucial for mitochondrial RNA metabolism, influencing the stability and expression of mitochondrial genes that are vital for energy production. The Lrpprc knockout cell lines enable researchers to dissect the role of LRPPRC in cellular processes such as mitochondrial dynamics, gene regulation, and overall cellular metabolism.

The fundamental mechanism of these cell lines involves the targeted deletion of the LRPPRC gene using CRISPR-Cas9 technology, resulting in predictable and reproducible phenotypic alterations. Researchers can observe the downstream effects on mitochondrial function, cellular viability, and associated metabolic pathways, providing valuable insights into disorders related to mitochondrial dysfunction, including various neurodegenerative diseases.

The significance of Lrpprc Gene Knockout Cell Lines extends to both basic research and clinical investigations. They serve as an essential tool for studying mitochondrial biology and the pathological mechanisms underlying diseases like Leigh syndrome and other mitochondrial disorders. Their application in drug discovery and toxicity testing further underscores their importance, allowing for more accurate modeling of human disease conditions.

Compared to alternative models, these knockout cell lines offer enhanced specificity and versatility, enabling researchers to explore the nuances of LRPPRC's function in vivo. Our product features rigorous validation and high reproducibility, which are critical for ensuring robust experimental outcomes.

For researchers, clinicians, and pharmaceutical developers alike, the Lrpprc Gene Knockout Cell Lines represent a significant advancement in elucidating complex biological pathways. Our commitment to quality and innovation is reflected in our extensive expertise in developing cutting-edge biological products tailored to the needs of the scientific community. With these cell lines, users can gain profound insights into mitochondrial function and its implications in health and disease, supporting their quests for novel therapeutic solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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