Gene: LSM1
Official Full Name: LSM1 homolog, mRNA degradation associatedprovided by HGNC
Gene Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27708 | LSM1 Knockout cell line (HeLa) | Human | LSM1 | 1:3~1:6 | Negative | Online Inquiry |
KO27709 | LSM1 Knockout cell line (HCT 116) | Human | LSM1 | 1:2~1:4 | Negative | Online Inquiry |
KO27710 | LSM1 Knockout cell line (HEK293) | Human | LSM1 | 1:3~1:6 | Negative | Online Inquiry |
KO27711 | LSM1 Knockout cell line (A549) | Human | LSM1 | 1:3~1:4 | Negative | Online Inquiry |
LSM1 Gene Knockout Cell Lines are genetically engineered cell lines in which the LSM1 gene has been selectively disrupted, serving as invaluable tools for studying gene function and regulatory mechanisms in cellular processes. The LSM1 (Like Sm protein 1) gene is primarily involved in mRNA decay and the regulation of RNA-binding proteins, playing a critical role in maintaining RNA homeostasis and cellular responses to environmental stressors. By knocking out the LSM1 gene, researchers can investigate its roles in post-transcriptional regulation, alternative splicing, and RNA metabolism, providing insights into various biological pathways and disease mechanisms.
These cell lines function by providing a controlled environment to assess the phenotypic consequences of LSM1 loss, facilitating functional assays that elucidate the gene’s contribution to cellular behavior. Mechanistically, the absence of LSM1 permits the exploration of how its signaling pathways interact with other cellular components, particularly in model systems relevant to cancer biology, neurodegeneration, and immune responses.
The scientific importance of LSM1 Gene Knockout Cell Lines extends to both research and clinical contexts. They are crucial for developing novel therapeutic strategies targeting RNA regulation and understanding the pathogenesis of related diseases. These models can be leveraged in high-throughput screening for potential drug candidates, allowing for accelerated discovery processes.
Unique to our offering, these knockout cell lines are produced using state-of-the-art CRISPR/Cas9 technology, ensuring precise and stable gene disruption. This approach guarantees reproducibility and reliability, giving researchers confidence in their experimental data. Compared to competitor products, our LSM1 Gene Knockout Cell Lines provide a higher level of validation and are accompanied by extensive technical support, ensuring seamless integration into existing workflows.
In conclusion, investing in LSM1 Gene Knockout Cell Lines represents a significant step forward for researchers and clinicians seeking to unlock the complexities of RNA regulation and its implications in health and disease. With our company’s commitment to excellence and innovation in genetic engineering, we are dedicated to supporting the scientific community's pursuit of advancing knowledge and improving therapeutic outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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