Gene: LRWD1
Official Full Name: leucine rich repeats and WD repeat domain containing 1provided by HGNC
Gene Summary: The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27152 | LRWD1 Knockout cell line (HeLa) | Human | LRWD1 | 1:3~1:6 | Negative | Online Inquiry |
KO27153 | LRWD1 Knockout cell line (HCT 116) | Human | LRWD1 | 1:2~1:4 | Negative | Online Inquiry |
KO27154 | LRWD1 Knockout cell line (HEK293) | Human | LRWD1 | 1:3~1:6 | Negative | Online Inquiry |
KO27155 | LRWD1 Knockout cell line (A549) | Human | LRWD1 | 1:3~1:4 | Negative | Online Inquiry |
LRWD1 Gene Knockout Cell Lines represent a pivotal tool in molecular biology research aimed at elucidating the functional role of the LRWD1 gene, a critical modulator in various cellular processes, including gene expression regulation and cancer progression. These cell lines have been meticulously engineered to have the LRWD1 gene selectively disrupted, allowing for the study of its contributions to cellular mechanisms without the confounding influence of its normal function.
The primary mechanism of action involves the CRISPR-Cas9 gene-editing technology, which ensures precise and efficient knockout of the target gene. By using these cell lines, researchers can investigate the phenotypic consequences of LRWD1 loss, assessing changes in cellular behavior, signaling pathways, and interactions with other biomolecules. This cellular model is particularly valuable in cancer research, where understanding the implications of LRWD1 deficiencies can reveal novel therapeutic targets or biomarkers for disease progression.
In the realm of scientific research, the availability of LRWD1 Gene Knockout Cell Lines offers distinct advantages over traditional methods, including stable gene knockout and the opportunity for high-throughput analysis. These cell lines empower researchers to conduct experiments that are pivotal for advancing our understanding of diseases linked to LRWD1, without the intricate processes typically required for creating knockout models in whole organisms, thus saving both time and resources.
For clinicians and researchers focused on cancer biology and therapeutic development, employing LRWD1 knockouts can facilitate the discovery of innovative treatments and improve patient outcomes through targeted therapies. The insights gained from studies utilizing these cell lines can transition from bench to bedside, addressing critical gaps in current knowledge and therapeutic strategies.
Our company possesses extensive experience and expertise in the development of sophisticated biological products, endorsed by a commitment to supporting the scientific community in their quest for knowledge and advancements in health. By choosing LRWD1 Gene Knockout Cell Lines, researchers are equipped with a cutting-edge resource that fosters ground-breaking discoveries and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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