Gene: LRRFIP2
Official Full Name: LRR binding FLII interacting protein 2provided by HGNC
Gene Summary: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33462 | LRRFIP2 Knockout cell line (HeLa) | Human | LRRFIP2 | 1:3~1:6 | Negative | Online Inquiry |
KO33463 | LRRFIP2 Knockout cell line (HCT 116) | Human | LRRFIP2 | 1:2~1:4 | Negative | Online Inquiry |
KO33464 | LRRFIP2 Knockout cell line (HEK293) | Human | LRRFIP2 | 1:3~1:6 | Negative | Online Inquiry |
KO33465 | LRRFIP2 Knockout cell line (A549) | Human | LRRFIP2 | 1:3~1:4 | Negative | Online Inquiry |
LRRFIP2 Gene Knockout Cell Lines represent a specialized tool for researchers investigating the role of the LRRFIP2 gene in cellular processes and disease mechanisms. These cell lines have undergone targeted genetic modification to completely eliminate the expression of the LRRFIP2 gene, enabling scientists to study the functional consequences associated with its absence. This knockout model serves as a vital resource for elucidating the gene's involvement in pathways such as immune response, cell signaling, and tumorigenesis.
The mechanisms underlying the functions of LRRFIP2 involve its engagement in modulating gene expression and contributing to the regulation of the inflammatory response. By utilizing these knockout cell lines, researchers can gain insights into how the loss of LRRFIP2 alters cellular behavior, activates compensatory pathways, or affects the response to stimuli, thereby advancing our understanding of a variety of biological processes and diseases.
The scientific importance of these cell lines spans both basic research and clinical applications. In laboratory settings, they can be instrumental in drug discovery and development, allowing for the identification of novel therapeutic targets. In translational research, these models are critical for investigating the potential of LRRFIP2 as a biomarker for certain conditions or as a target for therapeutic interventions in autoimmune diseases and cancers.
Compared to conventional models, LRRFIP2 Gene Knockout Cell Lines offer unique advantages including precise genetic editing, reproducibility in experiments, and the ability to model specific genetic conditions that mimic human diseases more accurately. This specificity enhances the reliability of experimental outcomes and paves the way for innovative treatments tailored to individual patient profiles.
For researchers and clinicians focused on gene function analysis and therapeutic development, the LRRFIP2 Gene Knockout Cell Lines are invaluable tools that provide critical insights and drive forward the boundaries of biological research. Our company is dedicated to advancing scientific discovery, backed by extensive expertise in genetic engineering and a commitment to delivering high-quality biological products to the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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