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LRIG2 Knockout Cell Lines

Gene: LRIG2

Official Full Name: leucine rich repeats and immunoglobulin like domains 2provided by HGNC

Gene Summary: This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32622 LRIG2 Knockout cell line (HeLa) Human LRIG2 1:3~1:6 Negative Online Inquiry
KO32623 LRIG2 Knockout cell line (HCT 116) Human LRIG2 1:2~1:4 Negative Online Inquiry
KO32624 LRIG2 Knockout cell line (HEK293) Human LRIG2 1:3~1:6 Negative Online Inquiry
KO32625 LRIG2 Knockout cell line (A549) Human LRIG2 1:3~1:4 Negative Online Inquiry

Background

LRIG2 Gene Knockout Cell Lines are specially developed cellular models that facilitate the study of the LRIG2 gene, which is known to play a critical role in regulating cellular signaling pathways, including those linked to cell growth and differentiation. These knockout cell lines are generated using advanced gene-editing technologies such as CRISPR-Cas9, ensuring the precise disruption of the LRIG2 gene in various mammalian cell types. The absence of LRIG2 allows researchers to investigate its biological functions and contributions to disease states, particularly in cancer, where its expression is often altered.

The key function of the LRIG2 Gene Knockout Cell Lines is to provide a controlled environment for examining the downstream effects of LRIG2 loss, including changes in signaling cascades and altered cellular behaviors like proliferation and apoptosis. By studying these modifications, scientists can uncover novel therapeutic targets and understand the pathophysiological mechanisms associated with diseases that exhibit aberrant LRIG2 expression.

In scientific research and clinical applications, these knockout cell lines serve as invaluable tools in drug discovery and validation, allowing for high-throughput screening of therapeutic compounds against specific tumor models. The ability to evaluate the effects of potential treatments in a genetically defined background nurtures more accurate and reproducible results, thereby enhancing the translational potential of preclinical studies.

Unlike conventional cell lines, which may represent heterogeneous genetic backgrounds, LRIG2 Gene Knockout Cell Lines guarantee uniformity, minimizing confounding variables. This specificity aids researchers in elucidating the precise roles of LRIG2 in various biological contexts, thus accelerating discoveries and advancing clinical research.

The LRIG2 Gene Knockout Cell Lines represent a pivotal resource for researchers aiming to unravel the complexities of cellular signaling and cancer biology. By leveraging our expertise in gene editing and cell line development, we offer high-quality, reliable models that empower scientists to push the boundaries of biological research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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