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LRFN1 Knockout Cell Lines

Gene: LRFN1

Official Full Name: leucine rich repeat and fibronectin type III domain containing 1provided by HGNC

Gene Summary: Predicted to be involved in regulation of postsynaptic density assembly. Predicted to be located in plasma membrane. Predicted to be active in cell surface; postsynaptic density membrane; and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16488 LRFN1 Knockout cell line (HeLa) Human LRFN1 1:3~1:6 Negative Online Inquiry
KO16489 LRFN1 Knockout cell line (HCT 116) Human LRFN1 1:2~1:4 Negative Online Inquiry
KO16490 LRFN1 Knockout cell line (HEK293) Human LRFN1 1:3~1:6 Negative Online Inquiry
KO16491 LRFN1 Knockout cell line (A549) Human LRFN1 1:3~1:4 Negative Online Inquiry

Background

LRFN1 Gene Knockout Cell Lines are specialized cellular models that have been engineered to disrupt the expression of the LRFN1 gene, which encodes the leucine-rich repeat and fibronectin type III domain-containing protein 1. These cell lines serve as a critical tool for researchers investigating the functional roles of LRFN1 in various biological processes, including cell adhesion, signaling pathways, and its contribution to disease pathology.

The key function of LRFN1 Gene Knockout Cell Lines lies in their ability to provide insights into the mechanistic consequences of LRFN1 loss-of-function. By utilizing CRISPR-Cas9 technology, these cell lines enable precise and efficient gene editing, leading to a complete knockout of LRFN1 expression. This allows researchers to study the resultant phenotypic changes, such as alterations in cellular morphology, proliferation rates, and migration capabilities, ultimately leading to a better understanding of LRFN1’s role in cellular dynamics and its implications in diseases such as cancer and neurodegenerative conditions.

The scientific importance of LRFN1 Gene Knockout Cell Lines is underscored by their applications in both fundamental and translational research. They can facilitate the discovery of novel therapeutic targets by elucidating the pathways influenced by LRFN1 and evaluating potential drug candidates in preclinical studies. Additionally, these cell lines provide a robust platform for screening compounds that can modulate the LRFN1-related signaling pathways, which may have significant implications for improving therapeutic strategies.

Compared to existing alternatives, such as conventional overexpression systems or chemical inhibition approaches, LRFN1 Gene Knockout Cell Lines offer a more precise mechanism for studying gene function devoid of off-target effects. This specificity enhances experimental reproducibility and reliability while minimizing confounding variables.

For researchers and clinicians seeking to deepen their understanding of the LRFN1 gene's role in health and disease, these knockout cell lines represent an invaluable resource. They not only empower investigations into the defined functions of this gene but also pave the way for future innovations in therapeutic development.

With a strong foundation of expertise in cutting-edge genetic engineering and a commitment to providing high-quality biological products, our company stands ready to support the research community with LRFN1 Gene Knockout Cell Lines and a wide array of other innovative solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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