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LPP Knockout Cell Lines

Gene: LPP

Official Full Name: LIM domain containing preferred translocation partner in lipomaprovided by HGNC

Gene Summary: This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36772 LPP Knockout cell line (HeLa) Human LPP 1:3~1:6 Negative Online Inquiry
KO36773 LPP Knockout cell line (HCT 116) Human LPP 1:2~1:4 Negative Online Inquiry
KO36774 LPP Knockout cell line (HEK293) Human LPP 1:3~1:6 Negative Online Inquiry
KO36775 LPP Knockout cell line (A549) Human LPP 1:3~1:4 Negative Online Inquiry

Background

LPP Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the expression of the LPP (Lipid Phosphate Phosphatase) gene. This innovative tool allows researchers to investigate the role of LPP in various biological processes, including cell growth, migration, and differentiation. By creating a knockout model, scientists can observe the phenotypic changes that occur in the absence of LPP, providing insights into its function in cellular signaling pathways and its potential contributions to disease states.

These cell lines operate through a targeted approach using CRISPR-Cas9 technology, which enables precise editing of the genome. This mechanism allows for the effective knockout of the LPP gene, resulting in the cessation of protein production associated with this gene, thereby facilitating controlled studies on its biological effects. Researchers can utilize LPP Gene Knockout Cell Lines in diverse applications ranging from basic biological research to more complex studies involving drug development and gene therapy.

The scientific importance of these cell lines is underscored by their potential applications in elucidating the roles of LPP in cancer biology, cardiovascular diseases, and wound healing. Understanding LPP's function could lead to the development of novel therapeutic strategies, marking a significant step forward in targeted treatments.

What sets LPP Gene Knockout Cell Lines apart from other genetic models is their reliable and reproducible knockout efficiency combined with the ease of use in experimental setups. Unlike alternative models that may have off-target effects or variable gene expression, these knockout cell lines provide a stable, consistent platform for researchers to derive meaningful and accurate data quickly.

By utilizing LPP Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful resource that enhances their investigations and strengthens the foundation for future discoveries. Our company prides itself on its extensive expertise in the production of high-quality biological tools and reagents that meet the demanding needs of the scientific community. Trust in our commitment to excellence to support your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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