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LPIN3 Knockout Cell Lines

Gene: LPIN3

Official Full Name: lipin 3provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09147 LPIN3 Knockout cell line (HeLa) Human LPIN3 1:3~1:6 Negative Online Inquiry
KO09148 LPIN3 Knockout cell line (HCT 116) Human LPIN3 1:2~1:4 Negative Online Inquiry
KO09149 LPIN3 Knockout cell line (HEK293) Human LPIN3 1:3~1:6 Negative Online Inquiry
KO09150 LPIN3 Knockout cell line (A549) Human LPIN3 1:3~1:4 Negative Online Inquiry

Background

LPIN3 Gene Knockout Cell Lines consist of genetically modified cellular models that lack the expression of the LPIN3 gene, which plays a critical role in lipid metabolism and energy regulation within cells. This innovative product enables researchers to explore the physiological and pathological implications of LPIN3 deficiency, contributing to a deeper understanding of metabolic disorders, obesity, and insulin resistance.

The key function of LPIN3 Gene Knockout Cell Lines lies in their ability to mimic the conditions of LPIN3 deficiency, allowing scientists to observe alterations in lipid droplet formation, fatty acid oxidation, and cellular signaling pathways. By employing techniques such as CRISPR-Cas9 gene editing, these cell lines effectively eliminate LPIN3 expression, enabling researchers to study its upstream and downstream regulatory mechanisms that are vital for maintaining cellular homeostasis.

In the scientific landscape, these knockout cell lines are essential tools in metabolic research and drug discovery. They can be utilized to assess the impact of potential therapeutic compounds and to investigate the role of LPIN3 in diseases such as type 2 diabetes and cardiovascular disorders. Their implications extend beyond basic research; LPIN3 knockout models may help in developing strategies for preventing and treating metabolic syndromes in clinical settings.

What sets LPIN3 Gene Knockout Cell Lines apart from traditional models is their precise genetic modification, which ensures reproducibility and high-quality data. Compared to other metabolic models, these cell lines offer researchers enhanced specificity and accuracy when exploring lipid metabolism, thereby facilitating more relevant and actionable findings.

Incorporating LPIN3 Gene Knockout Cell Lines into research protocols provides valuable insights that can lead to groundbreaking advancements in understanding metabolic diseases. Our company, with its focus on precision genetic tools and deep expertise in cellular models, is committed to delivering high-quality products that empower researchers and clinicians to make significant strides in their scientific inquiries and therapeutic developments.

Please note that all services are for research use only. Not intended for any clinical use.

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