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LPCAT3 Knockout Cell Lines

Gene: LPCAT3

Official Full Name: lysophosphatidylcholine acyltransferase 3provided by HGNC

Gene Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07073 LPCAT3 Knockout cell line (HeLa) Human LPCAT3 1:3~1:6 Negative Online Inquiry
KO07074 LPCAT3 Knockout cell line (HCT 116) Human LPCAT3 1:2~1:4 Negative Online Inquiry
KO07075 LPCAT3 Knockout cell line (HEK293) Human LPCAT3 1:3~1:6 Negative Online Inquiry
KO07076 LPCAT3 Knockout cell line (A549) Human LPCAT3 1:3~1:4 Negative Online Inquiry

Background

LPCAT3 Gene Knockout Cell Lines are specifically engineered cellular models that exhibit a complete knockout of the LPCAT3 gene, which is integral in phospholipid metabolism. Through the use of CRISPR-Cas9 gene editing technology, these cell lines are designed to facilitate the in-depth study of LPCAT3's role in various biological processes, particularly in relation to lipid metabolism and cellular physiology. By eliminating this gene, researchers can better understand its contributions to inflammation, lipid storage, and membrane dynamics.

The primary function of LPCAT3 within the cell is to catalyze the acylation of lysophosphatidylcholine, thus influencing the composition of cell membranes and the regulation of lipid signaling pathways. The knockout of LPCAT3 allows for the examination of compensatory mechanisms and alterations in lipid profiles, enabling scientists to explore the pathway interactions that modulate diseases such as atherosclerosis, obesity, and metabolic syndromes.

Scientifically, LPCAT3 gene knockout cell lines are invaluable for research and clinical applications. They provide a robust platform for drug discovery and testing, helping to identify potential therapeutic targets for lipid-related disorders. In clinical settings, understanding the molecular underpinnings of diseases associated with disrupted lipid metabolism can lead to the development of novel treatment strategies and personalized medicine approaches.

What sets LPCAT3 Gene Knockout Cell Lines apart from similar products on the market is their fidelity and reliability in modeling the LPCAT3 gene's absence, combined with the ease of use in various assays. Unlike alternative models that may offer incomplete insights, these knockout cell lines deliver reproducible and quantifiable results necessary for high-throughput screening and comprehensive mechanistic studies.

For researchers and clinicians, the ability to directly link gene function to cellular outcomes enhances the overall value of LPCAT3 knockout cell lines in advancing scientific knowledge and therapeutic innovations. Our company boasts extensive expertise in producing top-quality biological tools, ensuring that these models support your research needs with exceptional performance and consistency.

Please note that all services are for research use only. Not intended for any clinical use.

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