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LOXL3 Knockout Cell Lines

Gene: LOXL3

Official Full Name: lysyl oxidase like 3provided by HGNC

Gene Summary: This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24712 LOXL3 Knockout cell line (HeLa) Human LOXL3 1:3~1:6 Negative Online Inquiry
KO24713 LOXL3 Knockout cell line (HCT 116) Human LOXL3 1:2~1:4 Negative Online Inquiry
KO24714 LOXL3 Knockout cell line (HEK293) Human LOXL3 1:3~1:6 Negative Online Inquiry

Background

LOXL3 Gene Knockout Cell Lines are specially engineered cellular models that have had the lysyl oxidase-like 3 (LOXL3) gene disrupted or eliminated through targeted gene editing techniques, such as CRISPR/Cas9. These knockout cell lines serve as invaluable tools to investigate the biological functions and pathways influenced by LOXL3, a gene implicated in various physiological processes, including extracellular matrix remodeling and cellular differentiation.

The primary mechanism of action for LOXL3 involves the enzymatic cross-linking of collagen and elastin fibers, which are essential for maintaining tissue integrity and elasticity. By studying LOXL3 knockout cell lines, researchers can elucidate the gene's role in fibrotic diseases, cancer progression, and regenerative medicinal applications. As such, these cell lines are important in exploring therapeutic targets and understanding the molecular underpinnings of various diseases.

In comparison to other cell models, LOXL3 Gene Knockout Cell Lines offer several advantages, including enhanced specificity for LOXL3-related studies and the ability to assess downstream effects of LOXL3 gene loss under controlled experimental conditions. Unlike traditional methods that involve pharmacological inhibitors, these knockout lines provide precise insights into genetic contributions and can facilitate higher reproducibility in experimental outcomes.

For researchers and clinicians, the value of LOXL3 Gene Knockout Cell Lines is further emphasized by their potential to accelerate discovery in drug development, tissue engineering, and regenerative medicine. These models not only streamline research initiatives but also pave the way for innovative therapeutic strategies, enhancing the quest for effective treatments.

Our company is dedicated to advancing scientific knowledge through cutting-edge genetic models and tools. With expertise in molecular biology and a strong commitment to quality, we strive to support and empower researchers in their pioneering work with top-tier biological products like the LOXL3 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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