Gene: LLGL2
Official Full Name: LLGL scribble cell polarity complex component 2provided by HGNC
Gene Summary: The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08558 | LLGL2 Knockout cell line (HeLa) | Human | LLGL2 | 1:3~1:6 | Negative | Online Inquiry |
KO08559 | LLGL2 Knockout cell line (HCT 116) | Human | LLGL2 | 1:2~1:4 | Negative | Online Inquiry |
KO08560 | LLGL2 Knockout cell line (HEK293) | Human | LLGL2 | 1:3~1:6 | Negative | Online Inquiry |
KO08561 | LLGL2 Knockout cell line (A549) | Human | LLGL2 | 1:3~1:4 | Negative | Online Inquiry |
LLGL2 Gene Knockout Cell Lines are genetically modified cellular models designed to facilitate the in-depth study of the LLGL2 gene's role in cellular processes. LLGL2, or Lethal giant larvae homolog 2, is crucial for regulating cell polarity, proliferation, and differentiation. Through precise CRISPR-Cas9 gene editing technology, these cell lines exhibit a complete knockout of the LLGL2 gene, allowing researchers to investigate the resulting phenotypic changes and underlying mechanisms.
The functionality of LLGL2 knockout cell lines lies in their ability to model conditions relevant to cancer research, tissue development, and regenerative medicine. By observing cellular behavior in the absence of LLGL2, researchers can unveil potential pathways impacted by this gene, thereby gaining insights into tumorigenesis or developmental defects. These insights are vital in exploring potential therapeutic targets for conditions linked to aberrations in cell polarity and growth regulation.
Compared to traditional cell lines that may still express the LLGL2 protein, these knockout models offer unparalleled specificity and accuracy in results. This precision minimizes the confounding effects that often arise from incomplete gene silencing or off-target effects associated with other gene editing methods.
For researchers and clinicians, the LLGL2 Gene Knockout Cell Lines present a valuable tool that enhances the experimental rigor of studies involving LLGL2. They provide a robust platform for the investigation of gene function and the development of innovative therapeutic strategies.
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